Blog Archive

Saturday, August 21, 2021

08-21-2021-0026 - Activin A receptor, type I

 Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2(activin receptor-like kinase-2).[5] ACVR1 has been linked to the 2q23-24 region of the genome.[6] This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. While knock-out models with this gene are in progress, the ACVR1 gene has been connected to fibrodysplasia ossificans progressiva, a disease characterized by the formation of heterotopic bone throughout the body.[6] It is a bone morphogenetic protein receptor, type 1.

Function[edit]

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.[7]

Signaling[edit]

ACVR1 transduces signals of BMPs. BMPs bind either ACVR2A/ACVR2B or a BMPR2 and then form a complex with ACVR1. These go on to recruit the R-SMADs SMAD1SMAD2SMAD3 or SMAD6.[8]

Clinical significance[edit]

Gain-of-function mutations in the gene ACVR1/ALK2 is responsible for the genetic disease fibrodysplasia ossificans progressiva.[9] The typical FOP patient has the amino acid arginine substituted for the amino acid histidine at position 206 in this protein.[10][11] This causes a change in the critical glycine-serine activation domain of the protein which will cause the protein to bind its inhibitory ligand (FKBP12) less tightly, and thus over-activate the BMP/SMAD pathway.[6]The result of this over-activation is that endothelial cells transform to mesenchymal stem cells and then to bone.[12]Atypical mutations involving other residues work similarly - causing the protein to be stuck in its active conformation despite no BMP being present[13]

Mutations in the ACVR1 gene have also been linked to cancer, especially diffuse intrinsic pontine glioma(DIPG).[14][15][16]

https://en.wikipedia.org/wiki/ACVR1

08-20-2021-2345 - 25-year-old woman who had recovered from a bout of Covid-19 three weeks ago.

On Saturday morning, Dr Akshay Nair, a Mumbai-based eye surgeon, was waiting to operate on a 25-year-old woman who had recovered from a bout of Covid-19 three weeks ago.

Inside the surgery, an ear, nose and throat specialist was already at work on the patient, a diabetic. 

He had inserted a tube in her nose and was removing tissues infected with mucormycosis, a rare but dangerous fungal infection. This aggressive infection affects the nose, eye and sometimes the brain. 

After his colleague finished, Dr Nair would carry out a three hour procedure to remove the patient's eye.

"I will be removing her eye to save her life. That's how this disease works," Dr Nair told me.


https://www.bbc.com/news/world-asia-india-57027829


08-20-2021-2301- News

...The bodies of British man John Gerrish and his wife, Ellen Chung, and one-year-old daughter Miju were found in the Sierra National Forest on Tuesday.

Nearby waterways are being tested for toxic algae blooms, officials said.

Post-mortem examinations have been carried out in an effort to establish the cause of death....

"We don't know the cause… we won't rest until we figure it out," Mariposa County Sheriff Jeremy Briese told the Fresno Bee newspaper.

"There's no obvious indicators of how it occurred... you have two healthy adults, you have a healthy child and what appeared to be a healthy canine all within a general same area, deceased," he said.

Investigators suspected the deaths may have been linked to escaping gas from abandoned gold mines, but Mr Briese appeared to rule out that possibility on Thursday.

"I don't believe it's connected to a mine," he said. "It's frustrating and we're not going to rest... it's devastating to everyone."

"From what I've gathered, these algae blooms are due to the recent drought," Mr Briese said. "But I don't know too much detail about the toxicity of them."

Algae blooms can produce "extremely dangerous toxins that can sicken or kill people and animals", according to the US Environmental Protection Agency.

Last month, the US Forest Service posted warnings about the potentially toxic algae in the Sierra National Forest on Facebook.

"[The park] would like to inform those visitors who like to enjoy this area... not to swim, wade or allow their pets to enjoy the water," one post read.


https://www.bbc.com/news/world-us-canada-58288482

08-20-2021-2248 - News - Foreign - Middle East - Taliban Appearance (bf1900-1978+)

The militant Islamist group is said to be carrying out door-to-door searches while violent scenes have also been reported at some Taliban-controlled checkpoints.

The militants seized control of major cities last week as part of a sweeping offensive that shocked international observers. It culminated in the fall of the capital, Kabul, which triggered the collapse of the Afghan government.

"A neighbour said they were searching for weapons, documents and government vehicles. They were trying to find out who had worked for Nato or the government."

"They have twice called at my house... looking for me and my husband," one of the women, Aida, said. "They are asking other members of my family where we are and they have also been sending me threatening texts."

"They say that when they find me they will kill me."

"Right now we are like turkeys in our homes," her colleague, Saabira, said. "We can't go out because the Taliban are all around us." She said her food supplies were running worryingly low. 

"The Taliban are trying to find government [workers], journalists, and women's rights activists. We are really worried - what if they come to our home? What if they knock on our door?"

"The airport is not possible for us because we haven't [got a] visa" she said. "We haven't got money or any support, so it's impossible."

https://www.bbc.com/news/world-asia-58286372


The Taliban have stepped up their search for people who worked for Nato forces or the previous Afghan government, a report has warned.

It said the militants have been going door-to-door to find targets and threaten their family members.

The hardline Islamist group has tried to reassure Afghans since seizing power in a lightning offensive...

"It is in writing that, unless they give themselves in, the Taliban will arrest and prosecute, interrogate and punish family members on behalf of those individuals."

He warned that anyone on the Taliban's blacklist was in severe danger, and that there could be mass executions.

Their victory returns the group to power 20 years on from when they were toppled in a US-led invasion. 

The group's previous stint in power saw widespread abuses, including public executions and banning women from the workplace.


But in their first news conference since retaking control of Afghanistan, the group presented a conciliatory tone, promising women's rights would be respected "within the framework of Islamic law".


The Taliban have reportedly pledged not to force women to wear the burka - a one-piece veil that covers the face and body. Instead, the hijab - or a headscarf - will be compulsory.

They also said they did not want "any internal or external enemies" and that there would be an amnesty for former members of the security forces and those who worked with foreign powers.

https://www.bbc.com/news/world-asia-58271797




08-20-2021-2237 - Afghanistan Conflict 1978-Present

The Afghanistan conflict (Pashtoدافغانستان جنګونه‎; Persianجنگ های افغانستان‎) is a series of wars that has been fought in Afghanistan since 1978. Starting with the Saur Revolution military coup, an almost continuous series of armed conflicts has dominated and afflicted Afghanistan. The wars include:

It has been estimated that 1,405,111 to 2,084,468 lives have been lost since the start of the conflict.[4][5][6][7][8]

Rise and fall of communism[edit]

Prelude[edit]

Public transport in the peaceful Afghan capital Kabul in the 1950s

From 1933 to 1973 Afghanistan experienced a lengthy period of peace and relative stability.[10] It was ruled as a monarchy by King Zahir Shah, who belonged to the Afghan Musahiban Barakzai dynasty.[10][11] In the 1960s, Afghanistan as a constitutional monarchy held limited parliamentary elections.[12]

Zahir Shah, who would become the last King of Afghanistan, was overthrown by his cousin Mohammed Daoud Khan in July 1973, after discontent with the monarchy grew in the urban areas of Afghanistan.[10] The country had gone through several droughts, and charges of corruption and poor economic policies were leveled against the ruling dynasty. Khan transformed the monarchyinto a republic, and he became the first President of Afghanistan. He was supported by a faction of the People's Democratic Party of Afghanistan (PDPA), Afghanistan's communist party, which had been founded in 1965 and enjoyed strong relations with the Soviet Union. Neamatollah Nojumi writes in The Rise of the Taliban in Afghanistan: Mass Mobilization, Civil War, and the Future of the Region:

The establishment of the Republic of Afghanistan increased the Soviet investment in Afghanistan and the PDPA influence in the government's military and civil bodies.[13]

In 1976, alarmed by the growing power of the PDPA and the party's strong affiliation with the Soviet Union, Daoud Khan tried to scale back the PDPA's influence.[14] He dismissed PDPA members from their government posts, appointed conservative elements instead and finally announced the dissolution of the PDPA, arresting senior party members.[13]

Communist coup[edit]

Outside of the Presidential Palace in Kabul the day after the Saur Revolution, 28 April 1978

On 27 April 1978, the PDPA and military units loyal to the PDPA killed Daoud Khan, his immediate family and bodyguards in a violent coup, seizing control of the capital, Kabul.[15] As the PDPA had chosen a weekend holiday to conduct the coup, when many government employees were having a day off, Daoud Khan was not able to fully activate the well-trained armed forces which remained loyal to him to counter the coup.[15]

The new PDPA government, led by a revolutionary council, did not enjoy the support of the masses.[16] Therefore, it soon announced and implemented a hostile doctrine against any political dissent, whether inside or outside the party.[13] The first communist leader in Afghanistan, Nur Muhammad Taraki, was assassinated by his fellow communist Hafizullah Amin.[17] Amin was known for his independent and nationalist inclinations, and was also seen by many as a ruthless leader. He has been accused of killing tens of thousands of Afghan civilians at Pul-e-Charkhi and other national prisons: 27,000 politically motivated executions reportedly took place at Pul-e-Charkhi prison alone.[18]

Soviet intervention and withdrawal[edit]

The Soviet Union invaded Afghanistan on 24 December 1979, meeting only limited resistance. Amin was deposed from power almost immediately, as he and 200 of his guards were killed on 27 December by Soviet Army Spetsnaz, replaced by Babrak Karmal. After deployment into Afghanistan, Soviet forces along with government forces would begin to engage in a protracted counter-insurgency war with mujahideen fighters.

Soviet troops returning home from Afghanistan during the Soviet–Afghan War in 1986

The Soviet government realized that a military solution to the conflict would require far more troops. Because of this they discussed troop withdrawals and searched for a political and peaceful solution as early as 1980, but they never took any serious steps in that direction until 1988. Early Soviet military reports confirm the difficulties the Soviet army had while fighting on the mountainous terrain, for which the Soviet army had no training whatsoever. Parallels with the Vietnam War were frequently referred to by Soviet army officers.[19]

Policy failures, and the stalemate that ensued after the Soviet intervention, led the Soviet leadership to become highly critical of Karmal's leadership. Under Mikhail Gorbachev, the Soviet Union was able to depose Karmal and replace him with Mohammad Najibullah. Karmal's leadership was seen as a failure by the Soviet Union because of the rise of violence and crime during his administration.

Soviet Spetsnaz group prepares for a mission in 1988

Throughout the Soviet withdrawal from Afghanistan, troop convoys came under attack by Afghan rebel fighters. In all, 523 Soviet soldiers were killed during the withdrawal. The total withdrawal of all Soviet troops from Afghanistan was completed in February 1989.[20] The last Soviet soldier to leave was Lieutenant General Boris Gromov, leader of the Soviet military operations in Afghanistan at the time of the Soviet invasion.[21] In total 14,453 Soviet soldiers died during the Afghan war.

The Soviet war had a damaging impact on Afghanistan. The deaths of up to 2 million Afghans in the war has been described as "genocide" by a number of sources.[22][23][24] Five to ten million Afghans fled to Pakistan and Iran, amounting to 1/3 of the prewar population of the country, and another 2 million were displaced within the country. Pakistan's North-West Frontier Province functioned as an organisational and networking base for the anti-Soviet Afghan resistance, with the province's influential Deobandi ulama playing a major supporting role in promoting the 'jihad'.[25]

Fall of communism[edit]

After the Soviet withdrawal, the Republic of Afghanistan under Najibullah continued to face resistance from the various mujahideen forces. Najibullah received funding and arms from the Soviet Union until 1991 when the Soviet Union collapsed.[26] For several years the Afghan Army had actually increased their effectiveness past levels ever achieved during the Soviet military presence. But the government was dealt a major blow when Abdul Rashid Dostum, a leading general, created an alliance with the Shura-e Nazar of Ahmad Shah Massoud. Large parts of the Afghan communist government capitulated to the forces of Massoud in early 1992. After the Soviet defeat, The Wall Street Journalnamed Massoud "the Afghan who won the Cold War".[27] He had defeated the Soviet forces nine times in his home region of the Panjshir Valley in northeastern Afghanistan.[28]

Pakistan tried to install Gulbuddin Hekmatyar in power in Afghanistan against the opposition of all other mujahideen commanders and factions.[29] As early as October 1990, the Inter-Services Intelligence had devised a plan for Hekmatyar to conduct a mass bombardment of the Afghan capital Kabul with possible Pakistani troop enforcements.[29] This unilateral ISI-Hekmatyar plan came although the thirty most important mujahideen commanders had agreed on holding a conference inclusive of all Afghan groups to decide on a common future strategy.[29] Peter Tomsen reports that the protest by the other mujahideen commanders was like a "firestorm". Ahmad Zia Massoud, the brother of Ahmad Shah Massoud, said that his faction strongly opposed the plan and like other factions would take measures if any "Pakistani troops reinforced Hekmatyar". Abdul Haq was reportedly so angry about the ISI plan that he was "red in the face".[29] And Nabi Mohammad, another commander, pointed out that "Kabul's 2 million could not escape Hekmatyar's rocket bombardment – there would be a massacre."[29] Massoud's, Abdul Haq's and Amin Wardak's representatives said that "Hekmatyar's rocketing of Kabul ... would produce a civilian bloodbath."[29] The United States finally put pressure on Pakistan to stop the 1990 plan, which was subsequently called off until 1992.[29]

Islamic State and foreign interference[edit]

Flag of Hezb-e Islami. All of the Afghan political parties were unified under the Islamic State of Afghanistan in April 1992 except for Hezb-e Islami led by Gulbuddin Hekmatyar. Hezb-e Islami supported by Pakistan started a massive bombardment campaign against the Islamic State.

After the fall of Najibullah's government in 1992, the Afghan political parties agreed on a power-sharing agreement, the Peshawar Accord. The Peshawar Accord created the Islamic State of Afghanistan and appointed an interim government for a transitional period to be followed by general democratic elections. According to Human Rights Watch:

The sovereignty of Afghanistan was vested formally in the Islamic State of Afghanistan, an entity created in April 1992, after the fall of the Soviet-backed Najibullah government. [...] With the exception of Gulbuddin Hekmatyar's Hezb-e Islami, all of the parties [...] were ostensibly unified under this government in April 1992. [...] Hekmatyar's Hezb-e Islami, for its part, refused to recognize the government for most of the period discussed in this report and launched attacks against government forces and Kabul generally. [...] Shells and rockets fell everywhere.[30]

Gulbuddin Hekmatyar received operational, financial and military support from Pakistan.[31] Afghanistan expert Amin Saikal concludes in Modern Afghanistan: A History of Struggle and Survival:

Pakistan was keen to gear up for a breakthrough in Central Asia. [...] Islamabad could not possibly expect the new Islamic government leaders [...] to subordinate their own nationalist objectives in order to help Pakistan realize its regional ambitions. [...] Had it not been for the ISI's logistic support and supply of a large number of rockets, Hekmatyar's forces would not have been able to target and destroy half of Kabul.[32]

In addition, Saudi Arabia and Iran—as competitors for regional hegemony—supported Afghan militias hostility towards each other.[32]According to Human Rights Watch, Iran was assisting the Shia Hazara Hezb-i Wahdat forces of Abdul Ali Mazari, as Iran was attempting to maximize Wahdat's military power and influence.[30][32][33] Saudi Arabia supported the Wahhabite Abdul Rasul Sayyaf and his Ittihad-i Islami faction.[30][32] Conflict between the two militias soon escalated into a full-scale war. A publication by the George Washington University describes the situation:

[O]utside forces saw instability in Afghanistan as an opportunity to press their own security and political agendas.[34]

Due to the sudden initiation of the war, working government departments, police units or a system of justice and accountability for the newly created Islamic State of Afghanistan did not have time to form. Atrocities were committed by individuals of the different armed factions while Kabul descended into lawlessness and chaos as described in reports by Human Rights Watch and the Afghanistan Justice Project.[30][35] Because of the chaos, some leaders increasingly had only nominal control over their (sub-)commanders.[36] For civilians there was little security from murder, rape and extortion.[36] An estimated 25,000 people died during the most intense period of bombardment by Hekmatyar's Hezb-i Islami and the Junbish-i Milli forces of Abdul Rashid Dostum, who had created an alliance with Hekmatyar in 1994.[35] Half a million people fled Afghanistan.[36] Human Rights Watch writes:

Rare ceasefires, usually negotiated by representatives of Ahmad Shah MassoudSibghatullah Mojaddedi or Burhanuddin Rabbani [the interim government], or officials from the International Committee of the Red Cross (ICRC), commonly collapsed within days.[30]

Taliban rise to power[edit]

Southern Afghanistan was under the control of neither foreign-backed militias nor the government in Kabul, but was ruled by local leaders such as Gul Agha Sherzai and their militias. In 1994, the Taliban (a movement originating from Jamiat Ulema-e-Islam-run religious schools for Afghan refugees in Pakistan) also developed in Afghanistan as a politico-religious force, reportedly in opposition to the tyranny of the local governor.[37] Mullah Omar started his movement with fewer than 50 armed madrassah students in his hometown of Kandahar.[37] When the Taliban took control of the city in 1994, they forced the surrender of dozens of local Pashtun leaders who had presided over a situation of complete lawlessness and atrocities.[36] In 1994, the Taliban took power in several provinces in southern and central Afghanistan.

A totally destroyed section of Kabul in 1993.

In late 1994, most of the militia factions (Hezb-i Islami, Junbish-i Milli and Hezb-i Wahdat) which had been fighting in the battle for control of Kabul were defeated militarily by forces of the Islamic State's Secretary of Defense Ahmad Shah Massoud. Bombardment of the capital came to a halt.[35][38][39] Massoud tried to initiate a nationwide political process with the goal of national consolidation and democratic elections, also inviting the Taliban to join the process.[40] Massoud had united political and cultural personalities, governors, commanders, clergymen and representatives to reach a lasting agreement. Massoud, like most people in Afghanistan, saw this conference as a small hope for democracy and for free elections. His favourite for candidacy to the presidency was Dr. Mohammad Yusuf, the first democratic prime minister under Zahir Shah, the former king. In the first meeting representatives from 15 different Afghan provinces met, in the second meeting there were already 25 provinces participating. Massoud went unarmed to talk to several Taliban leaders in Maidan Shar, but the Taliban declined to join this political process.[40] When Massoud returned safely, the Taliban leader who had received him as his guest paid with his life: he was killed by other senior Taliban for failing to execute Massoud while the possibility was there.

The Taliban started shelling Kabul in early 1995 but were defeated by forces of the Islamic State government under Ahmad Shah Massoud.[38] Amnesty International, referring to the Taliban offensive, wrote in a 1995 report:

This is the first time in several months that Kabul civilians have become the targets of rocket attacks and shelling aimed at residential areas in the city.[38]

The Taliban's early victories in 1994 were followed by a series of defeats that resulted in heavy losses.[36] Pakistan provided strong support to the Taliban.[32][41] Many analysts like Amin Saikal describe the Taliban as developing into a proxy force for Pakistan's regional interests which the Taliban decline.[32]

On 26 September 1996, as the Taliban, with military support by Pakistan and financial support by Saudi Arabia, prepared for another major offensive, Massoud ordered a full retreat from Kabul.[42] The Taliban seized Kabul on 27 September 1996, and established the Islamic Emirate of Afghanistan.

Taliban Emirate against United Front[edit]

Taliban offensives[edit]

Map of the situation in Afghanistan in 1996: Ahmad Shah Massoud (red), Abdul Rashid Dostum (green) and Taliban (yellow) territories

The Taliban imposed on the parts of Afghanistan under their control their interpretation of Islam. The Physicians for Human Rights(PHR) stated that:

To PHR's knowledge, no other regime in the world has methodically and violently forced half of its population into virtual house arrest, prohibiting them on pain of physical punishment.[43]

Women were required to wear the all-covering burka, they were banned from public life and denied access to health care and education, windows needed to be covered so that women could not be seen from the outside, and they were not allowed to laugh in a manner that could be heard by others.[43] The Taliban, without any real court or hearing, cut people's hands or arms off when they were accused of stealing.[43] Taliban hit-squads watched the streets, conducting arbitrary brutal public beatings.[43]

The Taliban began preparing offensives against the remaining areas controlled by Ahmad Shah Massoud and Abdul Rashid Dostum. Massoud and Dostum, former foes, responded by allying to form the United Front (Northern Alliance) against the Taliban.[44] In addition to the dominantly Tajik forces of Massoud and the Uzbek forces of Dostum, the United Front included Hazara factions and Pashtunforces under the leadership of commanders such as Abdul Haq or Haji Abdul Qadir. Prominent politicians of the United Front were in example diplomat and Afghan prime minister Abdul Rahim Ghafoorzai or the UF's foreign minister Abdullah Abdullah. From the Taliban conquest in 1996 until November 2001 the United Front controlled roughly 30% of Afghanistan's population in provinces such as BadakhshanKapisaTakhar and parts of ParwanKunarNuristanLaghmanSamanganKunduzGhōr and Bamyan.

Taliban border guard

According to a 55-page report by the United Nations, the Taliban, while trying to consolidate control over northern and western Afghanistan, committed systematic massacres against civilians.[45][46] UN officials stated that there had been "15 massacres" between 1996 and 2001.[45][46]They also said, that "[t]hese have been highly systematic and they all lead back to the [Taliban] Ministry of Defense or to Mullah Omarhimself."[45][46] In a major effort to retake the Shomali plains, the Taliban indiscriminately killed civilians, while uprooting and expelling the population. Kamal Hossein, a special reporter for the UN, reported on these and other war crimes. Upon taking Mazar-i-Sharif in 1998, about 4,000 civilians were executed by the Taliban and many more reported tortured.[47][48] The Taliban especially targeted people of Shia religious or Hazara ethnic background.[45][46] Among those killed in Mazari Sharif were several Iranian diplomats. Others were kidnapped by the Taliban, touching off a hostage crisis that nearly escalated to a full-scale war, with 150,000 Iranian soldiers massed on the Afghan border at one time.[49]It was later admitted that the diplomats were killed by the Taliban, and their bodies were returned to Iran.[50]

The documents also reveal the role of Arab and Pakistani support troops in these killings.[45][46] Bin Laden's so-called 055 Brigade was responsible for mass-killings of Afghan civilians.[51] The report by the United Nations quotes eyewitnesses in many villages describing Arab fighters carrying long knives used for slitting throats and skinning people.[45][46]

Role of the Pakistani Armed Forces[edit]

Pakistan's intelligence agency, the Inter-Services Intelligence (ISI), wanted the Mujahideen to establish a government in Afghanistan. The director-general of the ISI, Hamid Gul, was interested in an Islamic revolution which would transcend national borders, not just in Afghanistan and Pakistan but also in Central Asia. To set up the proposed Mujahideen government, Hamid Gul ordered an assault on Jalalabad-with the intent on using it as the capital for the new government Pakistan was interested in establishing in Afghanistan.[52]

The Taliban were largely funded by Pakistan's ISI in 1994.[53][54][55][56][57][58][59][60] The ISI used the Taliban to establish a regime in Afghanistan which would be favorable to Pakistan, as they were trying to gain strategic depth.[61][62][63][64] Since the creation of the Taliban, the ISI and the Pakistani military have given financial, logistical and military support.[65][66][67]

According to Pakistani Afghanistan expert Ahmed Rashid, "between 1994 and 1999, an estimated 80,000 to 100,000 Pakistanis trained and fought in Afghanistan" on the side of the Taliban.[68] Peter Tomsen stated that up until 9/11 Pakistani military and ISI officers along with thousands of regular Pakistani Armed Forces personnel had been involved in the fighting in Afghanistan.[69]

In 2001 alone, according to several international sources, 28,000–30,000 Pakistani nationals, 14,000–15,000 Afghan Taliban and 2,000–3,000 Al Qaeda militants were fighting against anti-Taliban forces in Afghanistan as a roughly 45,000-strong military force.[40][51][70][71] Pakistani President Pervez Musharraf – then as Chief of Army Staff – was responsible for sending thousands of Pakistanis to fight alongside the Taliban and Bin Laden against the forces of Ahmad Shah Massoud.[40][41][72] Of the estimated 28,000 Pakistani nationals fighting in Afghanistan, 8,000 were militants recruited in madrassas filling regular Taliban ranks.[51] A 1998 document by the U.S. State Department confirms that "20–40 percent of [regular] Taliban soldiers are Pakistani."[41] The document further states that the parents of those Pakistani nationals "know nothing regarding their child's military involvement with the Taliban until their bodies are brought back to Pakistan."[41] According to the U.S. State Department report and reports by Human Rights Watch, the other Pakistani nationals fighting in Afghanistan were regular Pakistani soldiers especially from the Frontier Corps but also from the Pakistani Army providing direct combat support.[41][73]

Former Pakistani President Pervez Musharraf sent more troops against the United Front of Ahmad Shah Massoudthan the Afghan Taliban

Human Rights Watch wrote in 2000:

Of all the foreign powers involved in efforts to sustain and manipulate the ongoing fighting [in Afghanistan], Pakistan is distinguished both by the sweep of its objectives and the scale of its efforts, which include soliciting funding for the Taliban, bankrolling Taliban operations, providing diplomatic support as the Taliban's virtual emissaries abroad, arranging training for Taliban fighters, recruiting skilled and unskilled manpower to serve in Taliban armies, planning and directing offensives, providing and facilitating shipments of ammunition and fuel, and ... directly providing combat support.[73]

On 1 August 1997 the Taliban launched an attack on Sheberghan, the main military base of Abdul Rashid Dostum. Dostum has said the reason the attack was successful was that 1500 Pakistani commandos took part and that the Pakistani Air Force also gave support.[74]

In 1998 Iran accused Pakistani troops of war crimes at Bamiyan in Afghanistan and claimed that Pakistani warplanes had, in support of the Taliban, bombarded Afghanistan's last Shia stronghold.[75][76] The same year Russia said, Pakistan was responsible for the "military expansion" of the Taliban in northern Afghanistan by sending large numbers of Pakistani troops some of whom had subsequently been taken as prisoners by the anti-Taliban United Front.[77]

In 2000, the UN Security Council imposed an arms embargo against military support to the Taliban, with UN officials explicitly singling out Pakistan. The UN secretary-general implicitly criticized Pakistan for its military support and the Security Council stated it was "deeply distress[ed] over reports of involvement in the fighting, on the Taliban side, of thousands of non-Afghan nationals."[78] In July 2001, several countries including the United States, accused Pakistan of being "in violation of U.N. sanctions because of its military aid to the Taliban."[79] The Taliban also obtained financial resources from Pakistan. In 1997 alone, after the capture of Kabul by the Taliban, Pakistan gave $30 million in aid and a further $10 million for government wages.[80]

In 2000, British Intelligence reported that the ISI was taking an active role in several Al Qaeda training camps.[81] The ISI helped with the construction of training camps for both the Taliban and Al Qaeda.[81][82][83] From 1996 to 2001 the Al Qaeda of Osama Bin Laden and Ayman al-Zawahiri became a state within the Taliban state.[84] Bin Laden sent Arab and Central Asian Al-Qaeda militants to join the fight against the United Front, among them his Brigade 055.[84][85]

Anti-Taliban resistance[edit]

Ahmad Zia Massoud (left), the brother of anti-Taliban leader Ahmad Shah Massoud

Abdul Rashid Dostum and his forces were defeated by the Taliban in 1998. Dostum subsequently went into exile. The only leader to remain in Afghanistan, and who was able to defend vast parts of his area against the Taliban, was Ahmad Shah Massoud. In the areas under his control Ahmad Shah Massoud set up democratic institutions and signed the Women's Rights Declaration.[86] In the area of Massoud, women and girls did not have to wear the Afghan burqa. They were allowed to work and to go to school. In at least two known instances, Massoud personally intervened against cases of forced marriage.[40] To Massoud there was reportedly nothing worse than treating a person like an object.[40] He stated:

It is our conviction and we believe that both men and women are created by the Almighty. Both have equal rights. Women can pursue an education, women can pursue a career, and women can play a role in society — just like men.[40]

Author Pepe Escobar wrote in Massoud: From Warrior to Statesman:

Massoud is adamant that in Afghanistan women have suffered oppression for generations. He says that 'the cultural environment of the country suffocates women. But the Taliban exacerbate this with oppression.' His most ambitious project is to shatter this cultural prejudice and so give more space, freedom and equality to women — they would have the same rights as men.[40]

While it was Massoud's stated conviction that men and women are equal and should enjoy the same rights, he also had to deal with Afghan traditions which he said would need a generation or more to overcome. In his opinion that could only be achieved through education.[40] Humayun Tandar, who took part as an Afghan diplomat in the 2001 International Conference on Afghanistan in Bonn, said that "strictures of language, ethnicity, region were [also] stifling for Massoud. That is why ... he wanted to create a unity which could surpass the situation in which we found ourselves and still find ourselves to this day."[40] This applied also to strictures of religion. Jean-José Puig describes how Massoud often led prayers before a meal or at times asked his fellow Muslims to lead the prayer but also did not hesitate to ask a Christian friend Jean-José Puig or the Jewish Princeton Professor Michael Barry: "Jean-José, we believe in the same God. Please, tell us the prayer before lunch or dinner in your own language."[40]

Human Rights Watch cites no human rights crimes for the forces under direct control of Massoud for the period from October 1996 until the assassination of Massoud in September 2001.[87] One million people fled the Taliban, many to the area of Massoud.[88][89] National Geographic concluded in its documentary "Inside the Taliban":

The only thing standing in the way of future Taliban massacres is Ahmad Shah Massoud.[72]

The Taliban repeatedly offered Massoud a position of power to make him stop his resistance. Massoud declined. He explained in one interview:

The Taliban say: "Come and accept the post of prime minister and be with us", and they would keep the highest office in the country, the presidentship. But for what price?! The difference between us concerns mainly our way of thinking about the very principles of the society and the state. We can not accept their conditions of compromise, or else we would have to give up the principles of modern democracy. We are fundamentally against the system called "the Emirate of Afghanistan".[90]

And in another:

There should be an Afghanistan where every Afghan finds himself or herself happy. And I think that can only be assured by democracy based on consensus.[91]

Massoud with his Proposals for Peace wanted to convince the Taliban to join a political process leading towards nationwide democratic elections in a foreseeable future.[90]Massoud also stated:

The Taliban are not a force to be considered invincible. They are distanced from the people now. They are weaker than in the past. There is only the assistance given by Pakistan, Osama bin Laden and other extremist groups that keep the Taliban on their feet. With a halt to that assistance, it is extremely difficult to survive.[91]

In early 2001 Massoud employed a new strategy of local military pressure and global political appeals.[92] Resentment was increasingly gathering against Taliban rule from the bottom of Afghan society including the Pashtun areas.[92] Massoud publicized their cause of "popular consensus, general elections and democracy" worldwide. At the same time he was very wary not to revive the failed Kabul government of the early 1990s.[92] In 1999, he began training police forces specifically to keep order and protect the civilian population, in case the United Front was successful.[40]

In early 2001 Ahmad Shah Massoud addressed the European Parliament in Brussels asking the international community to provide humanitarian help to the people of Afghanistan.[93] (Video on YouTube) He stated that the Taliban and Al Qaeda had introduced "a very wrong perception of Islam" and that without the support of Pakistan and Bin Laden the Taliban would not be able to sustain their military campaign for up to a year.[94] On this visit to Europe he also warned that his intelligence had gathered information about a large-scale attack on U.S. soil being imminent.[95][failed verification][96] The president of the European Parliament, Nicole Fontaine, called him the "pole of liberty in Afghanistan".[97]

On 9 September 2001, Massoud, then aged 48, was the target of a suicide attack by two Arabs posing as journalists at Khwaja Bahauddin, in the Takhar Province of Afghanistan.[98][99] Massoud died in a helicopter taking him to a hospital. The funeral, though in a rather rural area, was attended by hundreds of thousands of mourning people.[100]

The assassination was not the first time Al-Qaeda, the Taliban, the Pakistani ISI, and before them the Soviet KGB, the Afghan Communist KHAD and Hekmatyar had tried to assassinate Massoud. He survived countless assassination attempts over a period of 26 years. The first attempt on Massoud's life was carried out by Hekmatyar and two Pakistani ISI agents in 1975, when Massoud was only 22 years old.[33] In early 2001, Al-Qaeda would-be assassins were captured by Massoud's forces while trying to enter his territory.[92]

9/11 connection[edit]

The assassination of Massoud is considered to have a strong connection to the September 11, 2001 attacks on the United States, which killed nearly 3000 people, and which appeared to be the terrorist attack that Massoud had warned against in his speech to the European Parliament several months earlier.[101]

John P. O'Neill was a counter-terrorism expert and the Assistant Director of the FBI until late 2001. He retired from the FBI and was offered the position of director of security at the World Trade Center (WTC). He took the job at the WTC two weeks before 9/11. On 10 September 2001, O'Neill allegedly told two of his friends, "We're due. And we're due for something big.... Some things have happened in Afghanistan. [referring to the assassination of Massoud] I don't like the way things are lining up in Afghanistan...I sense a shift, and I think things are going to happen...soon."[102] O'Neill died on 11 September 2001, when the South Tower collapsed.[102]

After the terrorist attacks of 11 September 2001, Massoud's United Front troops, with American air support, ousted the Taliban from power in Kabul in Operation Enduring Freedom. In November and December 2001, the United Front gained control of much of the country and played a crucial role in establishing the post-Taliban interim government of Hamid Karzai in late 2001.[103]

Islamic Republic and NATO[edit]

U.S. President George W. Bush and Hamid Karzai at the Presidential Palace in Kabul, Afghanistan.
Then – newly elected Afghan President Hamid Karzai stands in the center of a crowd of US soldiers from the US Special Forces Team Operational Detachment Alpha 574 during Operation Enduring Freedom in October 2001.

The US-led war in Afghanistan began on 7 October 2001, as Operation Enduring Freedom. It was designed to capture or kill Osama bin Laden and al-Qaeda militants, as well as replace the Taliban with a US-friendly government. The Bush Doctrine stated that, as policy, it would not distinguish between al-Qaeda and nations that harbor them.

Several Afghan leaders were invited to Germany in December 2001 for the UN sponsored Bonn Agreement, which was to restore stability and governance in their country. In the first step, the Afghan Transitional Administration was formed and was installed on 22 December 2001.[104] Chaired by Hamid Karzai, it numbered 30 leaders and included a Supreme Court, an Interim Administration, and a Special Independent Commission.

U.S. Marines of 1st Battalion, 6th Marines and an allied fighter near Siah Chub Kalay during Operation Asbury Park in 2004.
Soldiers of the Afghan National Army, including the ANA Commando Brigade standing in the front.

loya jirga (grand assembly) was convened in June 2002 by former King Zahir Shah, who returned from exile after 29 years. Hamid Karzai was elected president for the two years in the jirga, in which the Afghan Interim Authority was also replaced with the Transitional Islamic State of Afghanistan (TISA). A constitutional loya jirga was held in December 2003, adopting the new 2004 constitution, with a presidential form of government and a bicameral legislature.[105] Karzai was elected in the 2004 presidential election followed by winning a second term in the 2009 presidential election. Both the 2005 and the 2010 parliamentary elections were also successful.

In the meantime, the reconstruction process of Afghanistan began in 2002. There are more than 14,000 reconstruction projects under way in Afghanistan, such as the Kajaki and the Salma Dam.[106] Many of these projects are being supervised by the Provincial Reconstruction Teams. The World Bank contribution is the multilateral Afghanistan Reconstruction Trust Fund (ARTF), which was set up in 2002. It is financed by 24 international donor countries and has spent more than $1.37 billion as of 2007.[107] Approximately 30 billion dollars have been provided by the international community for the reconstruction of Afghanistan, most of it from the United States. In 2002, the world community allocated $4 billion at the Tokyo conference followed by another $4 billion in 2004. In February 2006, $10.5 billion were committed for Afghanistan at the London Conference[108] and $11 billion from the United States in early 2007. Despite these vast investments by the international community, the reconstruction effort's results have been mixed. Implementation of development projects at the district and sub-district level has been frequently marred by lack of coordination, knowledge of local conditions, and sound planning on the side of international donors as well as by corruption and inefficiency on the side of Afghan government officials. On the provincial and national level, projects such as the National Solidarity Programme, inter-provincial road construction, and the US-led revamping of rural health services have met with more success. As NATO prepares to withdraw the majority of remaining ISAF troops by the end of 2014, whether the Afghan government will be able to sustain the developmental gains made over the past 12 years, and to what extent international civilian aid organizations will be able to continue operations or refocus their efforts based on lessons learned, remains to be seen.

The UN Security Council established the International Security Assistance Force (ISAF) in December 2001 to provide basic security for the people of Afghanistan and assist the Karzai administration. Since 2002, the total number of ISAF and U.S. forces have climbed from 15,000 to 150,000. The majority of them belong to various branches of the United States Armed Forces, who are not only fighting the Taliban insurgency but also training the Afghan Armed Forces and Afghan National Police. They are scheduled to withdraw slowly until the end of 2014 but Vice President Joe Biden has proposed to retain an unknown number of U.S. military personnel after the 2014 deadline if the security situation required and the Afghan government and people desired.[109] Germany has announced that they will continue training Afghan police recruits after the 2014 withdrawal date for military troops.[110]

U.S. and Afghan troops in 2010.

NATO and Afghan troops led many offensives against the Taliban in this period. By 2009, a Taliban-led shadow government began to form, complete with their own version of mediation court.[111] In 2010, U.S. President Barack Obama deployed an additional 30,000 soldiers over a period of six months and proposed that he would begin troop withdrawals by 2012. At the 2010 International Conference on Afghanistan in LondonAfghan President Hamid Karzai said he intended to reach out to the Taliban leadership (including Mullah OmarSirajuddin Haqqani and Gulbuddin Hekmatyar). Supported by senior U.S. officials Karzai called on the group's leadership to take part in a loya jirga meeting to initiate peace talks. According to The Wall Street Journal, these steps were initially reciprocated with an intensification of bombings, assassinations and ambushes.[112]

Many Afghan groups (including the former intelligence chief Amrullah Saleh and opposition leader Dr. Abdullah Abdullah) believe that Karzai's plan aims to appease the insurgents' senior leadership at the cost of the democratic constitution, the democratic process and progress in the field of human rights, especially women's rights.[113] Dr. Abdullah stated:

I should say that Taliban are not fighting in order to be accommodated. They are fighting in order to bring the state down. So it's a futile exercise, and it's just misleading. ... There are groups that will fight to the death. Whether we like to talk to them or we don't like to talk to them, they will continue to fight. So, for them, I don't think that we have a way forward with talks or negotiations or contacts or anything as such. Then we have to be prepared to tackle and deal with them militarily. In terms of the Taliban on the ground, there are lots of possibilities and opportunities that with the help of the people in different parts of the country, we can attract them to the peace process; provided, we create a favorable environment on this side of the line. At the moment, the people are leaving support for the government because of corruption. So that expectation is also not realistic at this stage.[114]

According to a report by the United Nations, the Taliban were responsible for 76% of civilian casualties in 2009.[115] Afghanistan is currently struggling to rebuild itself while dealing with the results of 30 years of war, corruption among high-level politicians and the ongoing Taliban insurgency which according to different scientific institutes such as the London School of Economics, senior international officials, such as former United States Chairman of the Joint Chief of Staff Admrial Mike Mullen, believe the Taliban is backed by Pakistan's intelligence service.[116][117]

At the end of July 2010, the Netherlands became the first NATO ally to end its combat mission in Afghanistan after 4 years military deployment including the most intense period of hostilities. They withdrew 1,900 troops. The Atlantic Council described the decision as "politically significant because it comes at a time of rising casualties and growing doubts about the war."[118] Canada withdrew troops in 2011, but about 900 were left to train Afghani soldiers.[119][120]

In February 2012, a small number of American service members burned several copies of the Quran. Some Afghans responded with massive demonstrations and riots in Kabul and other areas. Assailants killed several American military personnel, including two officers in the Interior Ministry building following this event.

On 11 March 2012, an American soldier, Robert Bales, killed 16 civilians in the Kandahar massacre.

According to ISAF there were about 120,000 NATO-led troops in Afghanistan per December 2012, of which 66,000 were US troops and 9,000 British. The rest were from 48 different countries. A process of handing over power to local forces has started and according to plans a majority of international troops will leave in 2014.[121]

On 24 November 2013, President Karzai made a Loya jirga and put a ban on NATO house raids. This ban was put in place, and NATO soldiers were instructed to obey and follow this ban. In December 2013, a house raid in Zabul Province was exceptionally carried out by two NATO soldiers. Karzai condemned this in a highly publicised speech. On 3 January 2014 a bomb was heard by NATO soldiers in a base in Kabul; there were no reported casualties or injuries. The day after, a bomb hit a US military base in Kabul and killed one US citizen. The bomb was planted by the Taliban and the American service member was the first combat casualty in Afghanistan in that year. The Taliban immediately claimed responsibility for the attack.

On 1 May 2015 the media reported about a scheduled meeting in Qatar between Taliban insurgents and peacemakers, including the Afghan President, about ending the war.[122][123][124]

See also[edit]

Bibliography[edit]

References[edit]

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Further reading[edit]

External links[edit]

https://en.wikipedia.org/wiki/Afghanistan_conflict_(1978–present)

https://en.wikipedia.org/wiki/Mohammed_Omar

https://en.wikipedia.org/wiki/Dadullah

https://en.wikipedia.org/wiki/Hazaras#/media/File:Hazara_of_Daykundi_province.jpg