Blog Archive

Thursday, September 9, 2021

09-09-2021-1556 - As Children's COVID Cases Surge, There's Another Virus On The Rise respiratory syncytial virus. virus compounding

HEALTH

As Children's COVID Cases Surge, There's Another Virus On The Rise

August 14, 20217:00 AM ET



At the moment there is little data available on the impact of contracting COVID-19 and the respiratory syncytial virus (pictured), and whether together they can make a person sicker. But health officials worry it could put young patients — who are not eligible for the coronavirus vaccine — at greater risk.BSIP/UIG Via Getty Images/Universal Images Group via Getty

Early versions of COVID-19 largely spared children but the delta variant proved to be much less discriminating, and has led to more child hospitalizations. Now, health care workers on the front lines say there is another frightening prospect looming: a surge in children diagnosed with a combination of COVID-19 and respiratory syncytial virus.

Pediatric hospitals in Texas — and around the country — are reporting unseasonably early outbreaks of RSV, a respiratory virus that mostly manifests as a mild illness with cold-like symptoms in adults but that can cause pneumonia and bronchiolitis in very young children. The CDC reports it can be life-threatening in infants and young adults.

At Texas Children's Hospital in Houston on Thursday, 25 of 45 hospitalized pediatric patients were diagnosed with RSV as well as COVID-19. "A hospitalization rate much higher than for either virus alone," according to officials.

At the moment there is little data available on the impact of contracting both viruses and whether the two together can make a person sicker. But health officials worry it could put young patients — who are not eligible for the vaccine — at greater risk.

RSV infections are surging months earlier than normal
RSV infections typically occur in the late fall, winter and early spring, the CDC explains.

https://www.npr.org/2021/08/14/1027663917/rsv-covid-children

By at No comments:

09-09-2021-1539 - News

Montana reports 1,001 new COVID-19 cases, active cases reach 6,784 (Sept. 9 update)
https://www.ktvq.com/news/coronavirus/montana-reports-1-001-new-covid-19-cases-active-cases-reach-6-784-sept-9-update

WORLD
A Fire At A Field Hospital Set Up To Treat COVID-19 Patients Kills 14 People
September 9, 20219:07 AM ET
https://www.npr.org/2021/09/09/1035450638/north-macedonia-fire-covid-field-hospital

Utah tops 2,000 daily COVID-19 cases Thursday; 10 new deaths
https://www.fox13now.com/news/coronavirus/local-coronavirus-news/utah-tops-2-000-daily-covid-19-cases-thursday-10-new-deaths

More Kids Being Hospitalized With COVID-19
https://www.9and10news.com/2021/09/09/more-kids-being-hospitalized-with-covid-19/

Officials: Oregon infant dies from COVID-19 complications
UPDATED 17 HRS AGO | POSTED ON SEP 8, 2021  
https://www.kptv.com/news/officials-oregon-infant-dies-from-covid-19-complications/article_4703fad6-e4ff-51aa-b078-e7d07552047e.html

COVID-19 cases in South Dakota increase more than 450% since start of Sturgis Motorcycle Rally
BY CAITLIN O'KANE
UPDATED ON: AUGUST 27, 2021 / 10:14 AM / CBS NEWS
https://www.cbsnews.com/news/sturgis-rally-2021-south-dakota-covid-19-cases-surge/

COVID-19: inflammatory syndrome in children examined in new study
https://www.medicalnewstoday.com/articles/covid-19-rare-inflammatory-syndrome-in-children-examined-in-new-study

Unvaccinated pregnant nurse, unborn baby die after she contracts Covid
Haley Richardson's husband said she did not get the vaccination because she was concerned about how it could affect her pregnancy.
https://www.nbcnews.com/news/us-news/unvaccinated-pregnant-nurse-unborn-baby-die-after-she-contracts-covid-n1277611

Prognosis
The World May Never Reach Herd Immunity Against Covid-19
By Michelle Fay Cortez
August 13, 2021, 5:00 PM EDT Updated on August 16, 2021, 3:38 AM EDT
https://www.bloomberg.com/news/articles/2021-08-13/the-world-may-never-reach-herd-immunity-against-covid-19

US could soon hit more than 200,000 new coronavirus cases per day, NIH director warns
By Aya Elamroussi, Jamie Gumbrecht and Eric Levenson, CNN
Updated 9:53 PM ET, Sun August 15, 2021
https://www.cnn.com/2021/08/15/health/us-coronavirus-sunday/index.html

Global Covid-19 cases plateau after nearly two months of increase, WHO reports
By Lauren Mascarenhas and Nectar Gan, CNN
Updated 1:13 AM ET, Wed August 25, 2021
https://www.cnn.com/2021/08/25/world/who-covid-cases-plateau-intl-hnk/index.html

CDC adds 7 destinations to ‘very high’ Covid-19 travel risk list, including Puerto Rico and Switzerland
https://www.mercurynews.com/2021/08/31/cdc-adds-7-destinations-to-very-high-covid-19-travel-risk-list-including-puerto-rico-and-switzerland/

NIH study shows no significant benefit of convalescent plasma for COVID-19 outpatients with early symptoms
https://www.nih.gov/news-events/news-releases/nih-study-shows-no-significant-benefit-convalescent-plasma-covid-19-outpatients-early-symptoms

https://en.wikipedia.org/wiki/Chyle

First monoclonal antibody treatment for COVID-19 approved for use in the UK
The Medicines and Healthcare products Regulatory Agency (MHRA) has today given approval for the first monoclonal antibody treatment for the prevention and treatment of COVID-19 in the UK.
https://www.gov.uk/government/news/first-monoclonal-antibody-treatment-for-covid-19-approved-for-use-in-the-uk

Note. Code unit infiltration physics forces syncytin adhesion reduction decoherence ; filamentous viridae, plankto cota fungi prion misfold cascade. lipotics cancotics. forces cohesion unit acellular for trans. aerosol or std chem methroxetrate, industrial chem, additive pharmaceutical, etc..

https://www.nytimes.com/2021/09/09/health/first-covid-deaths.html


Biden may put future stimulus checks on autopilot — no vote required
Nancy Sarnoff
Thu, September 9, 2021, 7:22 PM·5 min read
https://finance.yahoo.com/news/biden-may-put-future-stimulus-232200868.html

 WSJ NEWS EXCLUSIVE  HEALTH POLICY
Biden Administration Releasing Billions in Covid-19 Relief for Hospitals, Health Groups
Disbursal of congressionally approved funding comes amid pressure from lawmakers to speed up effort
https://www.wsj.com/articles/biden-administration-releasing-billions-in-covid-19-relief-for-hospitals-health-groups-11631284543

https://bangordailynews.com/2021/09/08/news/penobscot/penobscot-nation-to-suspend-child-care-and-limit-other-services-due-to-covid-surge/
https://www.newscentermaine.com/article/news/health/coronavirus/coronavirus-numbers/medical-procedure-canceled-by-maine-medical-center-due-to-needing-covid-patients-space/97-ff251595-661f-4111-b453-f0736006ac7c
https://news.yahoo.com/maines-youth-prison-penobscot-county-113400509.html
https://www.maine.gov/dhhs/mecdc/infectious-disease/epi/airborne/coronavirus/index.shtml

Covid-19 data
The pandemic’s true death toll
Our daily estimate of excess deaths around the world
https://www.economist.com/graphic-detail/coronavirus-excess-deaths-estimates

Most Henry Ford Health employees got COVID-19 vaccine; Lawsuit withdrawn
https://www.clickondetroit.com/news/michigan/2021/09/10/most-henry-ford-health-employees-got-covid-19-vaccine-lawsuit-withdrawn/

Biden announces COVID-19 vaccine mandates that will affect 100 million Americans
by kathryn watson, nancy cordes, ed o'keefe, weijia jiang and fin gómez
UPDATED ON: SEPTEMBER 10, 2021 / 7:15 AM / CBS NEWS
https://www.cbsnews.com/live-updates/biden-covid-19-vaccine-mandates-announcement/

18 months of the COVID-19 pandemic – a retrospective in 7 charts
https://theconversation.com/18-months-of-the-covid-19-pandemic-a-retrospective-in-7-charts-166881

SBA quadruples COVID-19 EIDL limit to $2 million
By Jeff Drew 
September 9, 2021
https://www.journalofaccountancy.com/news/2021/sep/sba-raises-covid-19-eidl-limit-2-million.html

https://www.ajc.com/news/coronavirus/more-than-a-dozen-gorillas-at-zoo-atlanta-diagnosed-with-covid-19/K4XFA5FS5RATPJPZ4VKOCGOVJI/

Health & Wellness • Science & Technology
FDA-approved gout medicine could also battle COVID-19
11 hours ago
https://news.uga.edu/gout-medicine-could-also-battle-covid-19/


By at No comments:

09-09-2021-1515 - Lokivetmab

Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs.[1] It acts against interleukin 31(IL-31),[2] which is a cytokine involved in causing itchiness (pruritus).[2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks.[3]

The United States Department of Agriculture (USDA) approved lokivetmab (manufactured by Zoetis and sold under the trade name Cytopoint) in December 2016,[3] and it was approved by the European Medicines Agency in 2017.[4] Lokivetmab was the first monoclonal antibody to be approved for use in animals in the European Union.[4] 

https://en.wikipedia.org/wiki/Lokivetmab

By at No comments:

09-09-2021-1512 - Lenzilumab KB003 humanized monoclonal antibody - granulocyte-macrophage colony stimulating factor (GM-CSF)

Lenzilumab (INN; development code KB003)[1] is a humanized monoclonal antibody(class IgG1 kappa)[2] that targets colony stimulating factor 2 (CSF2)/granulocyte-macrophage colony stimulating factor (GM-CSF).

Pre-clinical evidence and clinical data implicate GM-CSF as a crucial initiator in the systemic inflammatory pathway driving the serious and life-threatening chimeric antigen receptor T cell (CAR-T) associated cytokine release syndrome (CRS). GM-CSF is produced by CAR-T cells upon recognition of target cells, which activates myeloid cells and compels them to produce monocyte chemoattractant protein 1 (MCP-1) and its receptor (CCR2).[3][4] GM-CSF knockout CAR-T cells protect mice from CRS; however, IL-6 knockout mice receiving wild-type CAR-T cells were not protected from CRS.[5] Moreover, mice infused with GM-CSF knockout CAR-T cells have significantly lower serum levels of MCP-1, IL-6, MIG, and MIP-1 than mice receiving wild-type CAR-T cells, demonstrating the role of GM-CSF signaling early in the inflammatory cascade. Administration of Lenzilumab in a patient-derived xenograft model significantly reduced CRS and neurotoxicity in mice, while preserving anti-leukemic efficacy.[6] A multi-center phase I/II trial including the MD Anderson Cancer Center will evaluate lenzilumab as prophylaxis for CRS and neurotoxicity in collaboration with Kite and is currently in recruitment.[7]

Additionally, GM-CSF has been shown to be instrumental in donor T-cell licensing of host and donor-derived myeloid cells in graft versus host disease (GVHD) following hematopoietic allotransplantation.[8][9] Mice receiving allografts deficient in GM-CSF have significantly reduced incidence and severity of GVHD.[10] A Phase II study with the University of Zürich and the United Kingdom's Stem Cell Transplantation IMPACT group will be investigating the efficacy of lenzilumab in prevention of acute GVHD and is currently in active planning.[11]

In light of the recent coronavirus disease 2019 (COVID-19) pandemic, the role of GM-CSF in the cytokine-mediated immunopathology of lung injury and acute respiratory distress syndrome (ARDS) has been under investigation. Plasma of hospitalized patients with confirmed COVID-19 has elevated levels of several inflammatory cytokines including IL-1B, IL-2, GM-CSF, IFN-γ, IP-10, MCP-1, MIP-1A/B, TNFα, and VEGF, indicative of a cytokine storm.[12] Importantly, significantly higher levels of MCP-1, MIP-1A, and IP-10 (all of which are downstream of GM-CSF) were found to be significantly higher in ICU-admitted patients versus hospitalized but non-ICU admitted patients. Another study found GM-CSF secreting CD8+ and CD4+ T-cells were higher in peripheral blood of ICU admitted patients in comparison to non-ICU admitted patients.[13] This correlated with a greater percentage of inflammatory monocytes and IL-6 secretion in peripheral blood. It is hypothesized soluble GM-CSF blockade with lenzilumab may dampen down myeloid cell recruitment and inflammatory cytokine production, thus reducing the incidence and severity of ARDS. A Phase III protocol for evaluating the efficacy of lenzilumab in the prevention and treatment of ARDS has been submitted to the FDA.[14]

Lenzilumab is under development by Humanigen Inc. and was originally designed for the treatment of chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML).[15][16][17] In vitro studies on human cells have demonstrated that Lenzilumab can induce sensitivity in myeloid and monocytic cells suggesting the antibody's applicability in CMML and JMML indications.[18] As of 2017, lenzilumab is currently undergoing clinical trials for CMML.[19][20] Prior to application in treating CMML, lenzilumab was assessed for use in treating inadequately controlled asthma[21] and rheumatoid arthritis.[22]

Covid-19[edit]

The NIH has chosen lenzilumab for its ACTIV-5 Big Effect trial.[23] [24]


 


FormulaC6474H10024N1748O2010S42
Molar mass145852.15 g·mol−1

https://en.wikipedia.org/wiki/Lenzilumab


By at No comments:

09-09-2021-1457 - COVID-19 pandemic data

Cases
219,000,000
Deaths
4,550,000
LocationCasesDeaths
United States
40,600,000
+184,000
653,000
+2,202
India
33,100,000
442,000
Brazil
20,900,000
+13,771
584,000
+313
United Kingdom
7,090,000
+38,486
134,000
+191
Russia
6,960,000

 https://en.wikipedia.org/wiki/Template:COVID-19_pandemic_data


By at No comments:
Subscribe to: Posts (Atom)