08012021-0720 - Genotoxation - NAC DOM USA
The genotoxic substances induce damage to the genetic material in the cells through interactions with the DNA sequence and structure. For example, the transition metal chromium interacts with DNA in its high-valent oxidation state so to incur DNA lesions leading to carcinogenesis. The metastable oxidation state Cr(V) is achieved through reductive activation. The researchers performed an experiment to study the interaction between DNA with the carcinogenic chromium by using a Cr(V)-Salen complex at the specific oxidation state.[3] The interaction was specific to the guanine nucleotide in the genetic sequence. In order to narrow the interaction between the Cr(V)-Salen complex with the guanine base, the researchers modified the bases to 8-oxo-G so to have site specific oxidation. The reaction between the two molecules caused DNA lesions; the two lesions observed at the modified base site were guanidinohydantoin and spiroiminodihydantoin. To further analyze the site of lesion, it was observed that polymerase stopped at the site and adenine was inappropriately incorporated into the DNA sequence opposite of the 8-oxo-G base.
https://en.wikipedia.org/wiki/Genotoxicity
MechanismExamples
Alkylating agents interfere with DNA replication and transcription by modifying DNA bases. Busulfan, Carmustine, Mechlorethamine
Intercalating agents interfere with DNA replication and transcription by wedging themselves into the spaces in between DNA's nucleotides Daunorubicin, Doxorubicin, Epirubicin
Enzyme inhibitors inhibit enzymes that are crucial to DNA replication Decitabine, Etoposide, Irinotecan
https://en.wikipedia.org/wiki/Genotoxicity
https://sites.google.com/view/spider2018cp/
https://en.wikipedia.org/wiki/Mineralization
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mineralization
https://en.wikipedia.org/wiki/Mineralization_(soil_science)
Radioactive nucleotide, radioactivity response, etc..
https://www.slideshare.net/SaadiyahNaeemi/transportation-of-oxygen-and-co2
https://en.wikipedia.org/wiki/Muscimol
https://pubchem.ncbi.nlm.nih.gov/compound/Ibotenic-acid
https://www.first-nature.com/fungi/coprinellus-micaceus.php
https://www.merriam-webster.com/dictionary/Ozonium
08-03-2021-1538 radioactive comp salt potas chlor trihydro cat distance incap wep fusor maser etc.
https://courses.lumenlearning.com/trident-boundless-chemistry/chapter/functional-group-names-properties-and-reactions/
https://sites.science.oregonstate.edu/~gablek/CH336/Chapter9/ethernom.htm
https://quizlet.com/38321816/chemistry-functional-groups-flash-cards/
https://slidetodoc.com/organic-chemistry-second-edition-david-klein-chapter-14-2/
https://www.fishersci.com/us/en/products/80003050/organic-compounds.html
https://commons.wikimedia.org/wiki/File:Oxane.png
https://www.researchgate.net/figure/The-structures-of-oxine-derivatives-with-entirely-di-ff-erent-mechanisms-of-action_fig6_266918026
http://www.chemdyes.net/index.php?route=product/product&product_id=4525
https://webbook.nist.gov/cgi/cbook.cgi?ID=R407155
https://en.wikipedia.org/wiki/Epoxy
https://www.britannica.com/science/epoxide
https://www.sciencedirect.com/topics/chemistry/oxirane
https://en.wikipedia.org/wiki/Baeyer–Villiger_oxidation
Biofilm, plaque, tartar, calculus, calcification/mineralization, liquefication
https://www.slideshare.net/JoylynConway/epoxides-functional-group
Granulation, Wound Healing, Tissue, Scar.
Epoxidification of human tissue; biofilm; etc..
Intercalating agent - mineral - and cascade/etc.. redox.
redox
https://pnghut.com/png/kRzGidn8bv/ethylene-oxide-glycol-carbonate-functional-group-4nitroquinoline-1oxide-transparent-png
Aerospace applications[edit]
In the aerospace industry, epoxy is used as a structural matrix material which is then reinforced by fiber. Typical fiber reinforcements include glass, carbon, Kevlar, and boron. Epoxies are also used as a structural glue. Materials like wood, and others that are 'low-tech' are glued with epoxy resin. Epoxies generally out-perform most other resin types in terms of mechanical properties and resistance to environmental degradation.[23]
Biology[edit]
Water-soluble epoxies such as Durcupan[24][25] are commonly used for embedding electron microscope samples in plastic so they may be sectioned (sliced thin) with a microtome and then imaged.[26]
https://en.wikipedia.org/wiki/Epoxy
https://www.researchgate.net/figure/Oxygen-containing-functional-groups-attached-to-grapheme_fig2_322932856
https://www.frontiersin.org/articles/10.3389/fenrg.2020.00142/full
ORIGINAL RESEARCH article
Front. For. Glob. Change, 03 September 2020 | https://doi.org/10.3389/ffgc.2020.00099
Soil Organic Matter Mineralization as Driven by Nutrient Stoichiometry in Soils Under Differently Managed Forest Stands
Huei Ying Gan1*, 
Ingo Schöning1, 
Peter Schall2, 
Christian Ammer2 and 
Marion Schrumpf11Max Planck Institute for Biogeochemistry, Jena, Germany
2Silviculture and Forest Ecology of the Temperate Zones, Georg-August University Göttingen, Göttingen, Germany
https://www.frontiersin.org/articles/10.3389/ffgc.2020.00099/full
https://scitechdaily.com/newly-discovered-quasicrystal-magnificent-in-its-complexity-was-created-by-the-first-nuclear-explosion-at-trinity-site/
https://www.grida.no/resources/7021
Continued...Explosion in a nitrogenous fertiliser plant 21 September 1921 07282021 draft
Moreover, the disaster highlights the effects of wind and temperature profiles in the upper atmosphere on sound propagation, generating the phenomenon of "silence zone". These geographical zones, which in the case of Oppau were located about 100 to 200 km from the explosion site, are zones where no sound from the explosion was heard whereas the sounds of the explosion were heard in a wider radius (until nearly 300 km in a case study).
https://www.aria.developpement-durable.gouv.fr/wp-content/files_mf/FD_14373_oppau_1921_ang.pdf
https://en.wikipedia.org/wiki/Flag_of_France
Acute lymphoblastic leukemia
https://en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia
http://www.thisdayinquotes.com/2019/05/luke-i-am-your-father-most-famous-movie.html
https://memegenerator.net/instance/69083853/luke-skywalker-and-darth-vader-luke-i-am-your-father
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