08-12-2021-2018 - drafting 1034

CLINICAL TRIALS AND OBSERVATIONS| DECEMBER 1, 2005

Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
Clinical Trials & Observations
Jacob M. Rowe,
Georgina Buck,
Alan K. Burnett,
Raj Chopra,
Peter H. Wiernik,
Susan M. Richards,
Hillard M. Lazarus,
Ian M. Franklin,
Mark R. Litzow,
Niculae Ciobanu,
H. Grant Prentice,
Jill Durrant,
Martin S. Tallman,
Anthony H. Goldstone,
for ECOG and the MRC/NCRI Adult Leukemia Working Party

Blood (2005) 106 (12): 3760–3767.
https://doi.org/10.1182/blood-2005-04-1623
Article

All patients received phase 1 of induction therapy (weeks 1-4),
which consisted of daunorubicin 60 mg/m2 administered intravenously on days 1, 8, 15, and 22;

Intercalation agent intercalating agent mineral intersertions cloning gen-mod genotoxins stolen child cover etc.; electrocution facilitation wh ex to DIW. Radioactive tag, hydrogen tags, etc.. DIW sensitive comps-composites-components-people/prop-etc., maser/taser/fusors/homemade oxygen hydrocat weps/hydro-oxy weps homemade/props et hydrags/etc., etc..

vincristine 1.4 mg/m2 administered intravenously on days 1, 8, 15, and 22;


alkylation agents, insecticides, antihepashityl drugs, americans/usa/u/amcan/etc., etc.


l-asparaginase 10 000 IU administered intravenously or intramuscularly on days 17 to 28 and

nuclear radionucleo nucleo parasites immunosuppression brain damage bone damage bone infarcts gas gangars liver failure splenomegaly bone-ful-gan-immunosuppression OR bone-gangars-no immunosuppression - phy no phy
;/ no euth ~ undef nc zero matrix zero vert america ch zer. chp = aggr to fg, w/ no euth upon res-fnd-disc-etc.

prednisone 60 mg/m2 administered orally in divided doses on days 1 to 28; and

hormonal-steriodal antiinflammatory ineffective, anabolic substrate lipolization/epoxification of tissues free radical induction oxidation redox dysfunction induction solid bone matrix decay necrosis immunosuppression irrev fibrotic scarrin on patients lungs etc.. leukemiaes dangers of cholesterol metabolic syndrome induction, diaetes mellitius, diabetes, obesity, deformity of skeleton/musculoskeletal, aferts, fat, lipmetdis, downreg of cachexia and depencency on physician for non effective and deleterious chemicals by law and in exchange for opiates/etc..

methotrexate 12.5 mg administered intrathecally on day 15 (Table 1).

insecticide, industrial chemical, chemosterilytic for insects, assault weapon, etc..

l-asparaginase was initially given at a high dose of 10 000/m2 to ECOG patients only from 1993 to 2000.

After analysis revealed that there was no difference in efficacy compared with 10 000 IU total, ECOG reverted to the lower dose of l-asparaginase.


Radiation

thyroid radioactive iodine and bone decay dental problems brain damage leading salts; utilization of radioactive potassium poisoning met/anti-cach/cell/etc. chemical weapon warefare testing public usa-amcan-nac-dom-etc., radioactive potash intrathecal injection with distance incap weps maser-taser-fusor-etc. same principles as all med equipment operants with radiation/radioactive-electrical alignments molecular componential/etc., etc..


cancer treatment proposed is ineffective entirely; pallative for physician mind. no cure proposed by component; no words.


ACUTE myel and alternative leukemiaes are indicated or evidenced in what environment only, what conditions of system what conditions of surroundings. Where constraints, confounds, bounds, equations, etc.. What is the measure and weights, etc.. Who decide.


Acute is not chron reoc.


HIV-HTLV-SIV-COVID19-DVT
Decay Matter
Fungal Leukemiae
Genmod clone trafficker fam-stolen child = america/NAC-DOM/USA/earth/etc.-et al., etc..
Bone degeneration - Mole/Hole/Malacia/Plaque/compress/bend/decay/necro/gans/etc. - Type 1
Intercalation Agent or Mineral present Lieuqfication (reference mineralization lieuqfication; osteomyelitis, gangrene) = Type 2
CL1=L5
- SSF 618

https://ashpublications.org/blood/article/106/12/3760/109755/Induction-therapy-for-adults-with-acute




aspargine, aspergillosis, aspergilia, asburgers






* heavy radiation-degredation-resistant drugs/pharmaceuticals/etc. as alkylation agents/cancer drugs/radionucleos/radioactive iodide/etc. etc. ~ bone






Rules
1.

08-12-2021-1729 - Trihydrogen Cation Conjecture/Model/hypothesis/theory/etc.



The trihydrogen cation or protonated molecular hydrogen is a cation (positive ion) with formula H+
3, consisting of three hydrogen nuclei (protons) sharing two electrons.

The trihydrogen cation is one of the most abundant ions in the universe. It is stable in the interstellar medium (ISM) due to the low temperature and low density of interstellar space. The role that H+
3 plays in the gas-phase chemistry of the ISM is unparalleled by any other molecular ion.

The trihydrogen cation is the simplest triatomic molecule, because its two electrons are the only valence electrons in the system. It is also the simplest example of a three-center two-electron bond system.

https://en.wikipedia.org/wiki/Trihydrogen_cation

https://nikiyaantonbettey.blogspot.com/2021/08/08-01-2021-1105-trihydrogen-cation-2021.html

2.
08-03-2021-1540 - AQ IMM + ST + COND

08-03-2021-1540 - AQ IMM + ST + COND

stepwise infections with actual not vaccine.

secondary metabolite antibiotics 'plant' (tobacco nicotine caffiene only) (Quote) [Reference Retained] nc nv nstp TS+ nr nc

amnestic mech pharm+tech (USA-GERM radioactive compound/radioactive/radioactive potassium/potaschlor/organophosphate/alkylation agent/etc. induced direct; short range typical use; on foot/persons near/etc.) tolerance conditioning (radioactive antagonist, alkylation agent antagonist, malic acid, acid, carbonated drink, caffiene, fluids, salt, acids, salts, iodine, acid bal., etc.)
Malic Acid/acid/etc. v. Alkylation Agent
Malic Acid/acid/acid-system/acid-salt/acid-salt system/etc. v. Alkylation Agent

Malic Acid/acid/acid-salt/hydrogen/etc. v. Alkylation Agent (Alkylation od problem; environment and techology and pharmaceutical alkylation attempt/alkalization of human; oxygen overdose; alkali nano explosives; organic volatile compound and ylide antagonists; positive ion disintegration/hydrogen gassing; negative chlorine/etc. ion wrong weight overload including bound; ion poisioning; ion poisioning by conditioning of ions; ion poisioning by coating; molecular and particle coatings; reactivity of coated particle env/etc.; hygroscopant poisioning; hydrazines; oxygen poisioning; nitrogen poisoning; atropine poisioning/oxime-type synthesis in body; sulphene exposure; sulfur type alkalis; deformed coated reactive nucleotide/atom/nitrogen/etc. incorp to prot bio by tech/pharm/amcan-war stolen ip/amcans and their stolen ip/etc.; fertilizer poisioning; cholesterol fractionalization techniques tubular female type; sterol overdose; sterioids/anabolic substances/anabolics/etc. overdose; salt poisioning; turpines/napthalenes/antpsy-experimental-requires life in unit no DL/ID/pinesol/household poisons/helium tanks/air compressors garage/antifreeze/hydrocarbon/starter fluid/carbons/insulation glass/glass human/engine materials/mechanic materials/building materials/epoxies/drain cleaner/window washing fluid/concrete cleaner/lubricants/silicones/transforms/WD40/bleach/oxygen-chlorine-etc. esp. long acting/etc./long acting pharmaceuticals/rat poison overdose/insecticide overdose/uv sterilizer overdose/sterilizer-sterilytic-etc. overdose/hormone overdose/small organic molecule/volatile lipid/gassification of lipid/cystulation of lipid particle/gassification of hydrocarbon/gassification of hydrocarbon with small sphericle release/hydrocat/non-tube feeding by gas vesicle/non-tube feeding by particle/weight gain by nano particle energy processes/weight gain by molecule consumption without digestive system/basal metabolic rate alteration with change of energy system/torture pharmaceuticals/etc.)

'research investigative pharmaceuticals' (Quote) [Reference Retained](est. 2015-2018)

amnestic mech pharm+tech+phys+unk+etc. (USA-GERM radioactive/organophos/etc. induced indirect; very-long (outerspace)/long range typical use; USA lab clandestine undground site NACDOM; e.g. BTR/alkylation agent/oxygen/alkali/radiation/brain trans/polymer brain/mod-brain/infusion/transfusion/etc./gene transplant/hybridization/genotoxin/etc., etc.)
tolerance conditioning (malic acid, acid, carbonated drink, acids, salts, iodine, acid bal.; nicotine; secondary metabolite, etc.; cellulose; hydrocolloid; yeast/buttermilk nf/baking powder/water/salt/etc., etc.);
chemical state match & double connect, sensory-signal/etc.
(sensory signal ops/interference/usurpation/fractionalization/rerouting/amplification/destruction/etc.); light particle imaging w/ data transfer
(VOC, VSP, light gas particle, particle with distinct/identifiable/etc. state change, cascade; cascade, dominos, chain reaction, chaining, chunking, trains, catalysts, transforms, solar/nuclear energy, inherent particle universe physics mechanical etc. modified by human signal transform etc., etc.; oxygen triangles cascade signaling (particle destruction signal; particle signal; particle cascade signal; particle matrix signal; particle fusion signal; particle fission signal; -- long range/very long range/etc.); trihydrogens; salts; ions; particles; light/energy emissions (emission receiver; chemical matrix receiver); etc.) w/ reality reconstruction reverse no aid (e.g. CMOS, etc.)(semiconductor, transformer, chips, sensors, radiation, spectrum expansion (nuclearization), terahertz, phonon, photon, proton, electron, ion, oxygen - the disappearing signal insulator?, insulators, etc.), database access for intel/signal comm USA (usually same channels/technology/regimen/etc. as incapacitation channels, with different arrangements/purpose/etc.), etc.)

Quote [Reference Retained] nc nv nstp ts nrk etc.
https://nikiyaantonbettey.blogspot.com/2021/08/08-03-2021-1540-aq-imm-st-cond.html


3.


Potassium chloride (KCl, or potassium salt) is a metal halide salt composed of potassium and chlorine. It is odorless and has a white or colorless vitreous crystal appearance. The solid dissolves readily in water, and its solutions have a salt-like taste. Potassium chloride can be obtained from ancient dried lake deposits.[7] KCl is used as a fertilizer,[8] in medicine, in scientific applications, and in food processing, where it may be known as E number additive E508.

It occurs naturally as the mineral sylvite, and in combination with sodium chloride as sylvinite.[9]

https://nikiyaantonbettey.blogspot.com/2021/08/08-01-2021-1107-potas-chlor.html




4.


https://www.fishersci.com/us/en/products/80003050/organic-compounds.html

https://commons.wikimedia.org/wiki/File:Oxane.png
https://www.researchgate.net/figure/The-structures-of-oxine-derivatives-with-entirely-di-ff-erent-mechanisms-of-action_fig6_266918026
http://www.chemdyes.net/index.php?route=product/product&product_id=4525
https://webbook.nist.gov/cgi/cbook.cgi?ID=R407155
https://en.wikipedia.org/wiki/Epoxy
https://www.britannica.com/science/epoxide
https://www.sciencedirect.com/topics/chemistry/oxirane
https://en.wikipedia.org/wiki/Baeyer–Villiger_oxidation

Biofilm, plaque, tartar, calculus, calcification/mineralization, liquefication [dental]

https://www.slideshare.net/JoylynConway/epoxides-functional-group


Granulation, Wound Healing, Tissue, Scar. [medical]


Epoxidification of human tissue; biofilm; etc.. [vet]


Intercalating agent - mineral - and cascade/etc.. redox. [vet]


redox


https://pnghut.com/png/kRzGidn8bv/ethylene-oxide-glycol-carbonate-functional-group-4nitroquinoline-1oxide-transparent-png


https://nikiyaantonbettey.blogspot.com/2021/08/08-04-2021-1932-intercalation.html




5.
illicit edit advisory

08-12-2021-1433 - Methotrexate Insecticide et Gene Resistance Caffinotic/Nicotinic/Toxin/etc. Antidoting, etc. - Indust Chemical Poisoning (insecticide sterilyant abortinoant immunosuppressant insecticide industrial chemical etc. - will rev-eng if time permit) Mimetics/Swaps/env-gassing/inj/subQ/IM/darting/tranquelizer anm/priming-predrugging-etc./etc. to fac rapid induction sequence to rapid alteration of consciousness-etc. with FOAS-FOS-etc. and etc./etc. by Sample Group (2020) [Street assault/any assault/etc. followed by B&I - infiltration where break/ent/tress by willing/self-pre-drugged assailants utilized non-incapacitant agent to selves (apathetic - drug type by eff), their mem retained - did not counter drug] with utilization of nuclear radioactive chemical/salt/gas/genotox/radnucs/not for human use/accomplice hcp prescription/DIW/Distance Incapacitation weps/incapacitation agent/etc. (e.g. field poisoning, waterproofs, genotoxins, L-Type C, paints, radioactive k, cesium ders, radon, neon, carbon silicide, gas chamber, aluminum, Dist inc weps, horse tranqs, dog immunosupprs, homemade, biohaz, industrial chems, insecticides, chemical warfare agents, cystulants, etc.). - In Field USA NAC DOM California. [year: 2016/2017-2019; 2018]

Antidote: Caffiene, Nicotine, aluminum/catalysts/etc., cleaning supply ammo-drain-aerosols-carpet pwd-insecticide counterant solvent-insecticide solvation-boric acid-etc., potox in field assembl, increase-change-etc. to antagonist/assailant poisoned field/etc. radioactive system by env x etc., carbonants (oxy-hydro type disintegrants micro), solvents, powders, precips/agglomeration mostly, Nuclear Field, Nitrogen Reduction, Glycerol/Propylene Glycol, Salting, Iodized Salt, PC, etc.
- Fungals used by sample group (2020) evidenced cultivation on CL1=L5 and were not responsive to typical antifungals including cyclins. Required C20H28O2 isotrets type to antagonize assault weapons utilized against victim (esp. bact, viri, fung, parasit, cystulation, genetic rate alteration, etc.; asslnts. caused a rate alterate over rate alterate see if vic survives only opti scenario, and without remittance of aggravant alterate). no pathway alteration; inst. rate alteration(desynchronization with assailants bioch-intended-aspiring-attempted-trying-schedule-state-rate-function-structrebrtch-etc. etc.). Calcium/Vit-C v. Iron (fluidation; iron over lead). bicarbonate soda, citric acid powder, etc.. piperonyl butes, butoxide, silicons, etc..


Ineffective: antineoplasics, retrovirals, alkylation, etc..


Consideration: baseline health, access to bsl, etc.. tech pharm adv. (both side; variant ranks).


Verdict: Assailants to utilize Insecticide Industrial Chemical Methrotroxations Orgphosphates and weapon to victim on CL1=L5.



Verdict: Assailants to utilize Insecticide Industrial Chemical Methrotroxations Orgphosphates and weapon to victim on CL1=L5. Assailants utilized/utilization of/utilize/to utilize Insecticide Industrial Chemical Methrotroxations Orgphosphates and weapon to/to incapacitation of/on/etc. victim on CL1=L5.


* Addition radioactive nucleotide nucleoradiotide radionucleotide radioactive potash potash rad-K radioactive potassium rad-hydrogen hydrotrits trihydrogen cation oxygen epox/ox/oxy-tri/etc., nitrogen, potas cat (alkali earth and alkali metals and halogen - chlorine, alcohol, potassium, sodium, cation poison, anion poisons, ion reversals, ylides, etc., etc..



Domains: Veterinary Med, Dental Med, Science, Eng, etc.. (american/amcans/united states/assailants/etc. with stolen intellectual property from the domains aforementioned to utilize for trafficking/brain transplant raid/assault/injury/mutilation/sterilization/amputation/conspiracy/crime/free-will/liberty/ideo. of constitution by theft of better and kept for self but not for you (ind-eal where share) -etc./etc., etc.)

Dr.Bettey, Robert/Nikiya/Dr. Anton, Steph-etc./Dr. Anton, A./etc. Rank - veterinarian engineer-(mechanical, etc.) psychologist psychiatrist immigrant scientist 'designer' Dentist Physician Birthright (no equals) White-skin Prussian-Blue [Located: USA NAC DOM ST 1900s]


Assailants Ranks - Amcan-American-United States-AziV-Layng West Germ Mix-BruenNeander-HIVPetersen-toxoplasmodWAde-IrvineTrafficker/Stolenchld/etc./Chris Walsh/ et al./USA/United States of America/NAC/DOM/etc. et al. etc., and their gangs.


Outcome: Nikiya et Bettey Separation perm.; Nikiya defection euthanasia. SSF. (overterm, overtime, missin records, framed id, etc.).

C20H28O2
ketone, hydroxy, ringulant, benzene,
https://en.wikipedia.org/wiki/Isotretinoin



08-12-2021-1433 - Methotrexate Insecticide et Gene Resistance Caffinotic/Nicotinic/Toxin/etc. Antidoting, etc. - Indust Chemical Poisoning of victims by Sample Group (2020)





https://nikiyaantonbettey.blogspot.com/2021/08/08-12-2021-1433-methotrexate.html




6.
08-12-2021-1433 - Methotrexate Insecticide et Gene Resistance Caffinotic/caffotinic/Nicotinic/Toxin/etc. Antidoting, etc. - Indust Chemical Insecticide Poisoning of victims by Sample Group (2020)

Caffeinated fruit flies help identify potential genes affecting insecticide resistanceDate:March 27, 2014Source:Genetics Society of AmericaSummary:To understand genetic mechanisms underlying insecticide resistance, scientists employed fruit flies and caffeine, a stimulant surrogate for xenobiotics in lab studies on resistance. Crop pests are capable of outwitting the chemical compounds known as xenobiotics that are devised to kill them. This development of resistance to insecticides is a serious problem because it threatens crop production and thereby can influence the availability and costs of many foods as well as the economy.https://www.sciencedaily.com/releases/2014/03/140327101417.htm

aminoimidazole caboxamide ribonucleotide transformylase (AICART), and amido phosphoribosyltransferase.1

Methotrexate is metabolized by folylpolyglutamate synthase to methotrexate polyglutamate in the liver as well as in tissues.1,7 Gamma-glutamyl hydrolase hydrolyzes the glutamyl chains of methotrexate polyglutamates converting them back to methotrexate.1,7 A small amount of methotrexate is also converted to 7-hydroxymethotrexate.1,7

INTERACTING GENE/ENZYMEALLELE NAMEGENOTYPE(S)DEFINING CHANGE(S)TYPE(S)Canalicular multispecific organic anion transporter 1ABCC2 IVS 23+56(C;C) / (C;T)T alleleADR Directly StudiedMethylenetetrahydrofolate reductase---(T;T) / (C;T)T alleleADR Directly Studied

Pharmacogenomic Effect/ADR for Methotrexate(DBSNPE000058)
DocumentationBrowse all
IdentifierDBSNPE000058DrugMethotrexate (DB00563)Interacting Gene/EnzymeCanalicular multispecific organic anion transporter 1Gene NameABCC2UniProt IDQ92887Defining Change(s)
T allele Not Available
Allele NameABCC2 IVS 23+56Genotype(s)(C;C) / (C;T)Type(s)ADR Directly StudiedGroupsNot AvailableDescriptionPatients with this genotype have increased risk of toxicity with methotrexate.References
Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ, Brasington R, Joseph A, Reddy V, Eisen S, McLeod HL: Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol. 2008 Apr;35(4):572-9. Epub 2008 Mar 15. [Article]


Limit caffeine intake. Caffeine may reduce the effectiveness of
Drug Categories
https://go.drugbank.com/drugs/DB00563

https://nikiyaantonbettey.blogspot.com/2021/08/08-12-2021-1433-methotrexate.html


7.




NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.[1][2][3][5][6] NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.[7][8][9][10][11][12]
https://en.wikipedia.org/wiki/NF-κB


957
https://nikiyaantonbettey.blogspot.com/2021/08/08-11-2021-1316-nf-b.html


8.

Wednesday, August 11, 2021

08-11-2021-1739 - Viroid



Viroids are small infectious pathogens.[1] They are composed solely of a short strand of circular, single-stranded RNA. Unlike viruses, they have no protein coating. All known viroids are inhabitants of angiosperms,[2]and most cause diseases, whose respective economic importance to humans varies widely.

The first discoveries of viroids in the 1970s triggered the historically third major extension of the biosphere—to include smaller lifelike entities —after the discoveries, in 1675 by Antonie van Leeuwenhoek (of the "subvisible" microorganisms) and in 1892/1898 by Dmitri Iosifovich Ivanovsky and Martinus Beijerinck (of the "submicroscopic" viruses). The unique properties of viroids have been recognized by the International Committee on Taxonomy of Viruses, in creating a new order of subviral agents.[3]

https://en.wikipedia.org/wiki/Viroid

By Nikiya Anton Bettey at August 11, 2021
https://nikiyaantonbettey.blogspot.com/2021/08/08-11-2021-1739-viroid.html


9.



08-11-2021-1715 - Pyrexia (missing original file; missing connecting work; etc.)




Pyrogens[edit]

A pyrogen is a substance that induces fever.[66] In the presence of an infectious agent, such as bacteria, viruses, viroids, etc., the immune response of the body is to inhibit their growth and eliminate them. The most common pyrogens are endotoxins, which are lipopolysaccharides (LPS) produced by Gram-negative bacteria such as E. coli. But pyrogens include non-endotoxic substances (derived from microorganisms other than gram-negative-bacteria or from chemical substances) as well.[67] The types of pyrogens include internal (endogenous) and external (exogenous) to the body.[citation needed]

The "pyrogenicity" of given pyrogens varies: in extreme cases, bacterial pyrogens can act as superantigens and cause rapid and dangerous fevers.[68]
Endogenous[edit]

Endogenous pyrogens are cytokines released from monocytes (which are part of the immune system).[69] In general, they stimulate chemical responses, often in the presence of an antigen, leading to a fever. Whilst they can be a product of external factors like exogenous pyrogens, they can also be induced by internal factors like damage associated from molecular patterns such as cases like rheumatoid arthritis or lupus.[70]

Major endogenous pyrogens are interleukin 1 (α and β)[71]:1237–1248 and interleukin 6 (IL-6).[72] Minor endogenous pyrogens include interleukin-8, tumor necrosis factor-β, macrophage inflammatory protein-α and macrophage inflammatory protein-β as well as interferon-α, interferon-β, and interferon-γ.[71]:1237–1248 Tumor necrosis factor-α (TNF) also acts as a pyrogen, mediated by interleukin 1 (IL-1) release.[73] These cytokine factors are released into general circulation, where they migrate to the brain's circumventricular organs where they are more easily absorbed than in areas protected by the blood–brain barrier.[citation needed] The cytokines then bind to endothelial receptors on vessel walls to receptors on microglial cells, resulting in activation of the arachidonic acid pathway.[citation needed]

Of these, IL-1β, TNF, and IL-6 are able to raise the temperature setpoint of an organism and cause fever. These proteins produce a cyclooxygenasewhich induces the hypothalamic production of PGE2 which then stimulates the release of neurotransmitters such as cyclic adenosine monophosphate and increases body temperature.[74]

https://nikiyaantonbettey.blogspot.com/2021/08/08-11-2021-1715-pyrexia-missing.html


10.

08-11-2021-0639 - Petersen et Wade etc. 4825 - Sample Group (2020) Note



Sample Group (2020)

Wade, S. - Examination of black-footed penguins with toxoplasmosis reveals hepatomegaly, splenomegaly, cranial hemorrhage, and necrotic kidneys (Ploeg, et al., 2011). Alveolar and hepatic tissue presents a high number of immune cells like macrophages containing tachyzoites of T. gondii.[76] Histopathological features in other animals affected with toxoplasmosis had tachyzoites in eye structures like the retina which lead to blindness.[76]

https://en.wikipedia.org/wiki/Toxoplasma_gondii

Petersen, S. - Lipopolysaccharides (LPS), also known as endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria. The term lipooligosaccharide ("LOS") is used to refer to a low-molecular-weight form of bacterial lipopolysaccharides.

Today, the term endotoxin is mostly used synonymously with LPS,[1] although there are a few endotoxins that are not related to LPS, such as the so-called delta endotoxin proteins secreted by Bacillus thuringiensis.

https://en.wikipedia.org/wiki/Lipopolysaccharide

Bacillus thuringiensis (or Bt) is a Gram-positive, soil-dwelling bacterium, the most commonly used biological pesticide worldwide

https://en.wikipedia.org/wiki/Bacillus_thuringiensis

Delta endotoxins (δ-endotoxins) are pore-forming toxins produced by Bacillus thuringiensis species of bacteria. They are useful for their insecticidal action and are the primary toxin produced by Bt corn. During spore formation the bacteria produce crystals of such proteins (hence the name Cry toxins) that are also known as parasporal bodies, next to the endospores; as a result some members are known as a parasporin. The Cyt (cytolytic) toxin group is a group of delta-endotoxins different from the Cry group.

cation-selective channels, which leads to death.[2][1]

A gene mostly found on plasmids,[4] delta-entotoxins sometimes show up in genomes of other species, albeit at a lower proportion than those found in B. thuringiensis.[5] The gene names looks like Cry3Bb, which in this case indicates a Cry toxin of superfamily 3 family B subfamily b.[6]

Cry proteins that are interesting to cancer research are listed under a parasporin (PS) nomenclature in addition to the Cry nomenclature. They do not kill insects, but instead kill leukemia cells.[7][8][9] The Cyt toxins tend to form their own group distinct from Cry toxins.[10] Not all Cry -- crystal-form -- toxins directly share a common root.[11] Examples of non-three-domain toxins that nevertheless have a Cry name include Cry34/35Ab1 and related beta-sandwich binary (Bin-like) toxins, Cry6Aa, and many beta-sandwich parasporins.[12]

In addition, Cry1Ac is effective as a vaccine adjuvant in humans.[14]

https://en.wikipedia.org/wiki/Delta_endotoxin

An endospore is a dormant, tough, and non-reproductive structure produced by some bacteria in the phylum Firmicutes.[1][2]

https://en.wikipedia.org/wiki/Endospore

Cry1Ac protoxin is a crystal protein produced by the gram-positive bacterium, Bacillus thuringiensis (Bt) during sporulation. Cry1Ac is one of the delta endotoxins produced by this bacterium which act as insecticides. Because of this, the genes for these have been introduced into commercially important crops by genetic engineering (such as cotton and corn) in order to confer pest resistance on those plants.[1][2][3]

Transgenic Bt cotton initially expressed a single Bt gene, which codes for Cry1Ac.[4] Subsequently, Bt cotton has added other delta endotoxins.[5] Products such as Bt cotton, Bt brinjal and genetically modified maize have received attention due to a number of issues, including genetically modified food controversies,[6][7][8] and the Séralini affair.[9][10]

Cry1Ac is also a mucosal adjuvant (an immune-response enhancer) for humans.[11][12][13] It has been used in research to develop a vaccine against the amoeba Naegleria fowleri.[14] This amoeba can invade and attack the human nervous system and brain, causing primary amoebic meningoencephalitis, which is nearly always fatal.

https://en.wikipedia.org/wiki/Cry1Ac
Toxins
enterotoxin
neurotoxin
hemotoxin
cardiotoxin
phototoxin


Activation of NF-κB: TRADD recruits TRAF2 and RIP. TRAF2 in turn recruits the multicomponent protein kinase IKK, enabling the serine-threonine kinaseRIP to activate it. An inhibitory protein, IκBα, that normally binds to NF-κB and inhibits its translocation, is phosphorylated by IKK and subsequently degraded, releasing NF-κB. NF-κB is a heterodimeric transcription factor that translocates to the nucleus and mediates the transcription of a vast array of proteins involved in cell survival and proliferation, inflammatory response, and anti-apoptotic factors.
https://en.wikipedia.org/wiki/Tumor_necrosis_factor


NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.[1][2][3][5][6] NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.[7][8][9][10][11][12]
https://en.wikipedia.org/wiki/NF-κB


Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. In humans it is usually found in males aged 30 to 40.[citation needed] It originates in fibrous tissues of the bone and invades long or flat bones such as the femur, tibia, and mandible. It also involves the periosteum and overlying muscle.
https://en.wikipedia.org/wiki/Fibrosarcoma





By Nikiya Anton Bettey at August 11, 2021
https://nikiyaantonbettey.blogspot.com/2021/08/08-11-2021-0639-petersen-et-wade-etc.html


11.


Wednesday, August 11, 2021

08-11-2021-0639 - Petersen et Wade etc. 4825 - Sample Group (2020) Note



Sample Group (2020)

Wade, s. - Examination of black-footed penguins with toxoplasmosis reveals hepatomegaly, splenomegaly, cranial hemorrhage, and necrotic kidneys (Ploeg, et al., 2011). Alveolar and hepatic tissue presents a high number of immune cells like macrophages containing tachyzoites of T. gondii.[76] Histopathological features in other animals affected with toxoplasmosis had tachyzoites in eye structures like the retina which lead to blindness.[76]

https://en.wikipedia.org/wiki/Toxoplasma_gondii

Petersen, s. - Lipopolysaccharides (LPS), also known as endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria. The term lipooligosaccharide ("LOS") is used to refer to a low-molecular-weight form of bacterial lipopolysaccharides.

Today, the term endotoxin is mostly used synonymously with LPS,[1] although there are a few endotoxins that are not related to LPS, such as the so-called delta endotoxin proteins secreted by Bacillus thuringiensis.

https://en.wikipedia.org/wiki/Lipopolysaccharide

Bacillus thuringiensis (or Bt) is a Gram-positive, soil-dwelling bacterium, the most commonly used biological pesticide worldwide

https://en.wikipedia.org/wiki/Bacillus_thuringiensis

Delta endotoxins (δ-endotoxins) are pore-forming toxins produced by Bacillus thuringiensis species of bacteria. They are useful for their insecticidal action and are the primary toxin produced by Bt corn. During spore formation the bacteria produce crystals of such proteins (hence the name Cry toxins) that are also known as parasporal bodies, next to the endospores; as a result some members are known as a parasporin. The Cyt (cytolytic) toxin group is a group of delta-endotoxins different from the Cry group.

cation-selective channels, which leads to death.[2][1]

A gene mostly found on plasmids,[4] delta-entotoxins sometimes show up in genomes of other species, albeit at a lower proportion than those found in B. thuringiensis.[5] The gene names looks like Cry3Bb, which in this case indicates a Cry toxin of superfamily 3 family B subfamily b.[6]

Cry proteins that are interesting to cancer research are listed under a parasporin (PS) nomenclature in addition to the Cry nomenclature. They do not kill insects, but instead kill leukemia cells.[7][8][9] The Cyt toxins tend to form their own group distinct from Cry toxins.[10] Not all Cry -- crystal-form -- toxins directly share a common root.[11] Examples of non-three-domain toxins that nevertheless have a Cry name include Cry34/35Ab1 and related beta-sandwich binary (Bin-like) toxins, Cry6Aa, and many beta-sandwich parasporins.[12]

In addition, Cry1Ac is effective as a vaccine adjuvant in humans.[14]

https://en.wikipedia.org/wiki/Delta_endotoxin

An endospore is a dormant, tough, and non-reproductive structure produced by some bacteria in the phylum Firmicutes.[1][2]

https://en.wikipedia.org/wiki/Endospore

Cry1Ac protoxin is a crystal protein produced by the gram-positive bacterium, Bacillus thuringiensis (Bt) during sporulation. Cry1Ac is one of the delta endotoxins produced by this bacterium which act as insecticides. Because of this, the genes for these have been introduced into commercially important crops by genetic engineering (such as cotton and corn) in order to confer pest resistance on those plants.[1][2][3]

Transgenic Bt cotton initially expressed a single Bt gene, which codes for Cry1Ac.[4] Subsequently, Bt cotton has added other delta endotoxins.[5] Products such as Bt cotton, Bt brinjal and genetically modified maize have received attention due to a number of issues, including genetically modified food controversies,[6][7][8] and the Séralini affair.[9][10]

Cry1Ac is also a mucosal adjuvant (an immune-response enhancer) for humans.[11][12][13] It has been used in research to develop a vaccine against the amoeba Naegleria fowleri.[14] This amoeba can invade and attack the human nervous system and brain, causing primary amoebic meningoencephalitis, which is nearly always fatal.

https://en.wikipedia.org/wiki/Cry1Ac
Toxins
enterotoxin
neurotoxin
hemotoxin
cardiotoxin
phototoxin


Activation of NF-κB: TRADD recruits TRAF2 and RIP. TRAF2 in turn recruits the multicomponent protein kinase IKK, enabling the serine-threonine kinaseRIP to activate it. An inhibitory protein, IκBα, that normally binds to NF-κB and inhibits its translocation, is phosphorylated by IKK and subsequently degraded, releasing NF-κB. NF-κB is a heterodimeric transcription factor that translocates to the nucleus and mediates the transcription of a vast array of proteins involved in cell survival and proliferation, inflammatory response, and anti-apoptotic factors.
https://en.wikipedia.org/wiki/Tumor_necrosis_factor


NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.[1][2][3][5][6] NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.[7][8][9][10][11][12]
https://en.wikipedia.org/wiki/NF-κB


Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. In humans it is usually found in males aged 30 to 40.[citation needed] It originates in fibrous tissues of the bone and invades long or flat bones such as the femur, tibia, and mandible. It also involves the periosteum and overlying muscle.
https://en.wikipedia.org/wiki/Fibrosarcoma





By Nikiya Anton Bettey at August 11, 2021
https://nikiyaantonbettey.blogspot.com/2021/08/08-11-2021-0639-petersen-et-wade-etc.html






12.

Wednesday, August 11, 2021

08-11-2021-0357 - CD30 TNFRSF87654



Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma is a cutaneous condition that usually presents as solitary or generalized plaques, nodules, or tumors of short duration.[1]:738




https://en.wikipedia.org/wiki/Non-mycosis_fungoides_CD30%E2%88%92_cutaneous_large_T-cell_lymphoma




CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.

https://en.wikipedia.org/wiki/CD30

https://nikiyaantonbettey.blogspot.com/2021/08/08-11-2021-0357-cd30-tnfrsf87654.html




13.

Wednesday, August 11, 2021

08-11-2021-0051 - Fungal Leukeamiaes - sp - fungus, fungal derivatives et priming by alkylation agents rads radk immunosups overvac genotox-viral gene transplant-activation of tumor gene-cell signal dysfunction/decay matter/fungai susecept/etc..






Pagetoid reticulosis (also known as "acral mycoses fungoides",[1] "localized epidermotropic reticulosis",[1] "mycosis fungoides palmaris et plantaris",[1] "unilesional mycosis fungoides",[2] and "Woringer–Kolopp disease"[1]) is a cutaneous condition, an uncommon lymphoproliferative disorder, sometimes considered a form of mycosis fungoides.[1]:734

https://en.wikipedia.org/wiki/Pagetoid_reticulosis




Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides,[1] is the most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally over time. Symptoms include rash, tumors, skin lesions, and itchy skin.



While the cause remains unclear, most cases are not hereditary. Most cases are in people over 20 years of age, and it is more common in men than women. Treatment options include sunlight exposure, ultraviolet light, topical corticosteroids, chemotherapy, and radiotherapy.

sp - fungus, fungal derivatives et priming by alkylation agents rads radk immunosups overvac genotox-viral gene transplant-activation of tumor gene-cell signal dysfunction/decay matter/fungai susecept/etc..

https://en.wikipedia.org/wiki/Mycosis_fungoides



While uncommon in solid tumors, chromosomal translocations are a common cause of these diseases. This commonly leads to a different approach in diagnosis and treatment of haematological malignancies.


CHRTRANS Leuk

A subgroup of them are more severe and are known as haematological malignancies (British English)/hematological malignancies (American English) or blood cancer. They may also be referred to as liquid tumors.[3][4]

Tumors of the hematopoietic and lymphoid tissues (American English) or tumours of the haematopoietic and lymphoid malignancies (British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system.[1][2]Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making myeloproliferation and lymphoproliferation (and thus the leukemiasand the lymphomas) closely related and often overlapping problems.

Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. The myeloid cell line normally produces granulocytes, erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin.

A subgroup of them are more severe and are known as haematological malignancies (British English)/hematological malignancies (American English) or blood cancer. They may also be referred to as liquid tumors.[3][4]

https://en.wikipedia.org/wiki/Tumors_of_the_hematopoietic_and_lymphoid_tissues

https://nikiyaantonbettey.blogspot.com/2021/08/08-11-2021-0051-fungal-leukeamiaes.html




14.

Lipopolysaccharides (LPS), also known as endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria. The term lipooligosaccharide ("LOS") is used to refer to a low-molecular-weight form of bacterial lipopolysaccharides.

Today, the term endotoxin is mostly used synonymously with LPS,[1] although there are a few endotoxins that are not related to LPS, such as the so-called delta endotoxin proteins secreted by Bacillus thuringiensis.

https://en.wikipedia.org/wiki/Lipopolysaccharide


15.


08-04-2021-1932 - Intercalation Alkylation Radioactive Potas Trihydrocat OxygenTri/ozone/etc. genotox rad DM DVM
https://nikiyaantonbettey.blogspot.com/2021/08/08-04-2021-1932-intercalation.html


16.


Wednesday, August 11, 2021

08-11-2021-0639 - Petersen et Wade etc. 4825 - Sample Group (2020) Note



Sample Group (2020)

Wade, Siboan. - Examination of black-footed penguins with toxoplasmosis reveals hepatomegaly, splenomegaly, cranial hemorrhage, and necrotic kidneys (Ploeg, et al., 2011). Alveolar and hepatic tissue presents a high number of immune cells like macrophages containing tachyzoites of T. gondii.[76] Histopathological features in other animals affected with toxoplasmosis had tachyzoites in eye structures like the retina which lead to blindness.[76]

https://en.wikipedia.org/wiki/Toxoplasma_gondii


HIV AIDS LEUK HEP

The World Health Organization first proposed a definition for AIDS in 1986.[26] Since then, the WHO classification has been updated and expanded several times, with the most recent version being published in 2007.[26] The WHO system uses the following categories:
Primary HIV infection: May be either asymptomatic or associated with acute retroviral syndrome[26]
Stage I: HIV infection is asymptomatic with a CD4+ T cell count (also known as CD4 count) greater than 500 per microlitre (µl or cubic mm) of blood.[26] May include generalized lymph node enlargement.[26]
Stage II: Mild symptoms, which may include minor mucocutaneous manifestations and recurrent upper respiratory tract infections. A CD4 count of less than 500/µl[26]
Stage III: Advanced symptoms, which may include unexplained chronic diarrhea for longer than a month, severe bacterial infections including tuberculosis of the lung, and a CD4 count of less than 350/µl[26]
Stage IV or AIDS: severe symptoms, which include toxoplasmosis of the brain, candidiasis of the esophagus, trachea, bronchi, or lungs, and Kaposi's sarcoma. A CD4 count of less than 200/µl[26]


Specific adverse events are related to the antiretroviral agent taken.[170] Some relatively common adverse events include: lipodystrophy syndrome, dyslipidemia, and diabetes mellitus, especially with protease inhibitors.[25] Other common symptoms include diarrhea,[170][171] and an increased risk of cardiovascular disease.[172] Newer recommended treatments are associated with fewer adverse effects.[29] Certain medications may be associated with birth defects and therefore may be unsuitable for women hoping to have children.[29]



The rash, which occurs in 20–50% of cases, presents itself on the trunk and is maculopapular, classically.[29]
The most common initial conditions that alert to the presence of AIDS are pneumocystis pneumonia (40%), cachexia in the form of HIV wasting syndrome (20%), and esophageal candidiasis.[28] Other common signs include recurrent respiratory tract infections.[28]
People with AIDS have an increased risk of developing various viral-induced cancers, including Kaposi's sarcoma, Burkitt's lymphoma, primary central nervous system lymphoma, and cervical cancer.[29]

The World Health Organization first proposed a definition for AIDS in 1986.[26] Since then, the WHO classification has been updated and expanded several times, with the most recent version being published in 2007.[26] The WHO system uses the following categories:
Primary HIV infection: May be either asymptomatic or associated with acute retroviral syndrome[26]
Stage I: HIV infection is asymptomatic with a CD4+ T cell count (also known as CD4 count) greater than 500 per microlitre (µl or cubic mm) of blood.[26] May include generalized lymph node enlargement.[26]
Stage II: Mild symptoms, which may include minor mucocutaneous manifestations and recurrent upper respiratory tract infections. A CD4 count of less than 500/µl[26]
Stage III: Advanced symptoms, which may include unexplained chronic diarrhea for longer than a month, severe bacterial infections including tuberculosis of the lung, and a CD4 count of less than 350/µl[26]
Stage IV or AIDS: severe symptoms, which include toxoplasmosis of the brain, candidiasis of the esophagus, trachea, bronchi, or lungs, and Kaposi's sarcoma. A CD4 count of less than 200/µl[26]
Specific adverse events are related to the antiretroviral agent taken.[170] Some relatively common adverse events include: lipodystrophy syndrome, dyslipidemia, and diabetes mellitus, especially with protease inhibitors.[25]Other common symptoms include diarrhea,[170][171] and an increased risk of cardiovascular disease.[172] Newer recommended treatments are associated with fewer adverse effects.[29] Certain medications may be associated with birth defects and therefore may be unsuitable for women hoping to have children.[29]

...became a poster child for HIV after being expelled from school because he was infected.[269]

Diseases of poverty

AIDS
Malaria
Tuberculosis
Measles
Pneumonia
Diarrheal diseases
Plague
Neglected diseases

Cholera
Chagas disease
African sleeping sickness
Schistosomiasis
Dracunculiasis
River blindness
Leishmaniasis
Trachoma
Miscellaneous

Malnutrition
Priority review voucher

https://en.wikipedia.org/wiki/HIV/AIDS



https://en.wikipedia.org/wiki/HIV/AIDS


Petersen, Sharon/Shannon/etc.. - Lipopolysaccharides (LPS), also known as endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria. The term lipooligosaccharide ("LOS") is used to refer to a low-molecular-weight form of bacterial lipopolysaccharides.

Today, the term endotoxin is mostly used synonymously with LPS,[1] although there are a few endotoxins that are not related to LPS, such as the so-called delta endotoxin proteins secreted by Bacillus thuringiensis.

https://en.wikipedia.org/wiki/Lipopolysaccharide

Bacillus thuringiensis (or Bt) is a Gram-positive, soil-dwelling bacterium, the most commonly used biological pesticide worldwide

https://en.wikipedia.org/wiki/Bacillus_thuringiensis

Delta endotoxins (δ-endotoxins) are pore-forming toxins produced by Bacillus thuringiensis species of bacteria. They are useful for their insecticidal action and are the primary toxin produced by Bt corn. During spore formation the bacteria produce crystals of such proteins (hence the name Cry toxins) that are also known as parasporal bodies, next to the endospores; as a result some members are known as a parasporin. The Cyt (cytolytic) toxin group is a group of delta-endotoxins different from the Cry group.

cation-selective channels, which leads to death.[2][1]

A gene mostly found on plasmids,[4] delta-entotoxins sometimes show up in genomes of other species, albeit at a lower proportion than those found in B. thuringiensis.[5] The gene names looks like Cry3Bb, which in this case indicates a Cry toxin of superfamily 3 family B subfamily b.[6]

Cry proteins that are interesting to cancer research are listed under a parasporin (PS) nomenclature in addition to the Cry nomenclature. They do not kill insects, but instead kill leukemia cells.[7][8][9] The Cyt toxins tend to form their own group distinct from Cry toxins.[10] Not all Cry -- crystal-form -- toxins directly share a common root.[11] Examples of non-three-domain toxins that nevertheless have a Cry name include Cry34/35Ab1 and related beta-sandwich binary (Bin-like) toxins, Cry6Aa, and many beta-sandwich parasporins.[12]

In addition, Cry1Ac is effective as a vaccine adjuvant in humans.[14]

https://en.wikipedia.org/wiki/Delta_endotoxin

An endospore is a dormant, tough, and non-reproductive structure produced by some bacteria in the phylum Firmicutes.[1][2]

https://en.wikipedia.org/wiki/Endospore

Cry1Ac protoxin is a crystal protein produced by the gram-positive bacterium, Bacillus thuringiensis (Bt) during sporulation. Cry1Ac is one of the delta endotoxins produced by this bacterium which act as insecticides. Because of this, the genes for these have been introduced into commercially important crops by genetic engineering (such as cotton and corn) in order to confer pest resistance on those plants.[1][2][3]

Transgenic Bt cotton initially expressed a single Bt gene, which codes for Cry1Ac.[4] Subsequently, Bt cotton has added other delta endotoxins.[5] Products such as Bt cotton, Bt brinjal and genetically modified maize have received attention due to a number of issues, including genetically modified food controversies,[6][7][8] and the Séralini affair.[9][10]

Cry1Ac is also a mucosal adjuvant (an immune-response enhancer) for humans.[11][12][13] It has been used in research to develop a vaccine against the amoeba Naegleria fowleri.[14] This amoeba can invade and attack the human nervous system and brain, causing primary amoebic meningoencephalitis, which is nearly always fatal.

https://en.wikipedia.org/wiki/Cry1Ac
Toxins
enterotoxin
neurotoxin
hemotoxin
cardiotoxin
phototoxin


Activation of NF-κB: TRADD recruits TRAF2 and RIP. TRAF2 in turn recruits the multicomponent protein kinase IKK, enabling the serine-threonine kinaseRIP to activate it. An inhibitory protein, IκBα, that normally binds to NF-κB and inhibits its translocation, is phosphorylated by IKK and subsequently degraded, releasing NF-κB. NF-κB is a heterodimeric transcription factor that translocates to the nucleus and mediates the transcription of a vast array of proteins involved in cell survival and proliferation, inflammatory response, and anti-apoptotic factors.
https://en.wikipedia.org/wiki/Tumor_necrosis_factor


NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.[1][2][3][5][6] NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.[7][8][9][10][11][12]
https://en.wikipedia.org/wiki/NF-κB


Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. In humans it is usually found in males aged 30 to 40.[citation needed] It originates in fibrous tissues of the bone and invades long or flat bones such as the femur, tibia, and mandible. It also involves the periosteum and overlying muscle.
https://en.wikipedia.org/wiki/Fibrosarcoma





By Nikiya Anton Bettey at August 11, 2021




17.
Verdict: Assailants to utilize Insecticide Industrial Chemical Methrotroxations Orgphosphates and weapon to victim on CL1=L5. Assailants utilized/utilization of/utilize/to utilize Insecticide Industrial Chemical Methrotroxations Orgphosphates and weapon to/to incapacitation of/on/etc. victim on CL1=L5.


* Addition radioactive nucleotide nucleoradiotide radionucleotide radioactive potash potash rad-K radioactive potassium rad-hydrogen hydrotrits trihydrogen cation oxygen epox/ox/oxy-tri/etc., nitrogen, potas cat (alkali earth and alkali metals and halogen - chlorine, alcohol, potassium, sodium, cation poison, anion poisons, ion reversals, ylides, etc., etc..


18.