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Sunday, February 12, 2023

02-11-2023-2110 - Nonsense-mediated mRNA decay (NMD)

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons.[1] Translation of these aberrant mRNAs could, in some cases, lead to deleterious gain-of-function or dominant-negative activity of the resulting proteins.[2] 

https://en.wikipedia.org/wiki/Nonsense-mediated_decay

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