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Thursday, September 9, 2021

09-08-2021-1845 - Phaeohyphomycosis fungal filament filamentous dematiaceous fungal melanin virulence factor phaeo hyp hypho pho pha aeo air mycosis fungus

 Phaeohyphomycosis is a diverse group of fungal infections,[6] caused by dematiaceous fungi whose morphologic characteristics in tissue include hyphae, yeast-like cells, or a combination of these.[7]:324 It can be associated an array of melanistic filamentous fungi including Alternaria species,[8] Exophiala jeanselmei,[9] and Rhinocladiella mackenziei.[10]

The term “phaeohyphomycosis” was introduced to determine infections caused by dematiaceous (pigmented) filamentous fungi which contain melanin in their cell walls.[11] Phaeohyphomycosis is an uncommon infection, however the number of case reported has been increasing in recent years. Fungal melanin is thought to be a virulence factor. The outcome of antifungal treatment is poor, and mortality is almost 80%.[12] Phaeohyphomycosis has been attributed to more than 100 species and 60 genera of fungi over the past several decades. The pathogens are considered opportunistic. Almost all cases of widely disseminated infection have occurred in immunosuppressed people.[12]

https://en.wikipedia.org/wiki/Phaeohyphomycosis


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