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Tuesday, October 12, 2021

10-12-2021-0219 - Plasmablastic lymphoma (PBL)

 Plasmablastic lymphoma (PBL) is a type of large B-cell lymphoma recognized by the World Health Organization (WHO) in 2017 as belonging to a subgroup of lymphomas termed lymphoid neoplasms with plasmablastic differentiation. The other lymphoid neoplasms within this subgroup are: plasmablastic plasma cell lymphoma (or the plasmacytoma variant of this disease); primary effusion lymphoma that is Kaposi's sarcoma-associated herpesvirus positive or Karposi's sarcoma-associated Herpesvirus negativeanaplastic lymphoma kinase-positive large B-cell lymphoma; and human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified. All of these lymphomas are malignancies of plasmablasts, i.e. B-cells that have differentiated into plasmablasts but because of their malignantnature: fail to differentiate further into mature plasma cells; proliferate excessively; and accumulate in and injure various tissues and organs.[1]

https://en.wikipedia.org/wiki/Plasmablastic_lymphoma

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