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Showing posts with label tuberculosis. Show all posts
Showing posts with label tuberculosis. Show all posts

Wednesday, September 1, 2021

09-01-2021-1751 - Caseous necrosis or caseous degeneration

Caseous necrosis or caseous degeneration[1] (/ˈkeɪsiÉ™s/)[2] is a unique form of cell death in which the tissue maintains a cheese-like appearance.[3] It is also a distinctive form of coagulative necrosis.[4] The dead tissue appears as a soft and white proteinaceous dead cell mass.

Micrograph showing caseous necrosis of a tuberculous lymph node. H&E stain. Histological specimens are normally obtained from supraclavicular lymph nodes to demonstrate caseous necrosis.

Frequently, caseous necrosis is encountered in the foci of tuberculosis infections.[3] It can also be caused by syphilis and certain fungi.

A similar appearance can be associated with histoplasmosiscryptococcosis, and coccidioidomycosis.[6]

Some data suggests that the epithelioid morphology and associated barrier function of host macrophages associated with granulomas may prevent effective immune clearance of mycobacteria.[9]

https://en.wikipedia.org/wiki/Caseous_necrosis