09-08-2021-0937 - Primary myelofibrosis (PMF) is a rare bone marrow blood cancer.[1] ' This is most often associated with a somatic mutation in the JAK2, CALR, or MPL gene markers. In PMF, the healthy marrow is replaced by scar tissue (fibrosis), '

 Primary myelofibrosis (PMF) is a rare bone marrow blood cancer.^[1] It is classified by the World Health Organization (WHO) as a type of myeloproliferative neoplasm, a group of cancers in which there is growth of abnormal cells in the bone marrow. This is most often associated with a somatic mutation in the JAK2, CALR, or MPL gene markers. In PMF, the healthy marrow is replaced by scar tissue (fibrosis), resulting in a lack of production of normal blood cells. Symptoms include anemia, increased infection and an enlarged spleen (splenomegaly).

In 2016, prefibrotic primary myelofibrosis was formally classified as a distinct condition that progresses to overt PMF in many patients, the primary diagnostic difference being the grade of fibrosis.^[2]

Primary myelofibrosis
Other names	PMF, Overt PMF, Myelofibrosis
Specialty	Oncology and Hematology

https://en.wikipedia.org/wiki/Primary_myelofibrosis

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