The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteinsresponsible for the regulation of the immune system.[1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.[2]
Mutations in HLA genes may be linked to autoimmune disease such as type I diabetes, and celiac disease. The HLA gene complex resides on a 3 Mbpstretch within chromosome 6, p-arm at 21.3. HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system. The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants.[3]
https://en.wikipedia.org/wiki/Human_leukocyte_antigen
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