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| Clinical data | |
|---|---|
| Pronunciation | AR se nik tri OKS id |
| Trade names | Trisenox, others |
| Other names | Arsenic(III) oxide, Arsenic sesquioxide, Arseneous oxide, Ratsbane, Arseneous anhydride, White arsenic, Aqua Tofani[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a608017 |
| License data |
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| Pregnancy category |
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| Routes of administration | Intravenous |
| Drug class | Antineoplastic agent |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 75% |
| Excretion | Urine |
| Identifiers | |
| CAS Number | |
|---|---|
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.014.075 |
| Chemical and physical data | |
| Formula | As2O3 |
| Molar mass | 197.840 g·mol−1 |
| 3D model (JSmol) | |
| Density | 3.74 g/cm3 |
| Melting point | 312.2 °C (594.0 °F) |
| Boiling point | 465 °C (869 °F) |
| Solubility in water | 20 g/L (25 °C) (see text) |
| Identifiers | |
|---|---|
| ECHA InfoCard | 100.014.075 |
| EC Number |
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CompTox Dashboard (EPA)
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| Hazards | |
| GHS labelling:[2] | |
   
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| Danger | |
| H300, H314, H350, H410 | |
| P201, P202, P260, P264, P270, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340+P310, P305+P351+P338+P310, P308+P313, P363, P391, P405, P501 | |
| Safety data sheet (SDS) | american elements SDS |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound with the formula As
2O
3.[3] As an industrial chemical, its major uses include the manufacture of wood preservatives, pesticides, and glass.[4] It is also used as a medication[5] to treat a type of cancer known as acute promyelocytic leukemia.[5] For this use it is given by injection into a vein.[5]
Common side effects include vomiting, diarrhea, swelling, shortness of breath, and headaches.[5] Severe side effects may include APL differentiation syndrome and heart problems.[5] Use during pregnancy or breastfeeding may harm the baby.[6][7] Its mechanism in treating cancer is not entirely clear.[5]
Arsenic trioxide was approved for medical use in the United States in 2000.[5] It is on the World Health Organization's List of Essential Medicines.[8] Approximately 50,000 tonnes are produced a year.[9] Due to its toxicity, a number of countries have regulations around its manufacture and sale.[10]
https://en.wikipedia.org/wiki/Arsenic_trioxide
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