08-01-2021-0210 - Methyl vinyl sulphone: a new class of Michael-type genotoxin 1990

. 1990 Nov;245(3):191-9. doi: 10.1016/0165-7992(90)90049-p.
Methyl vinyl sulphone: a new class of Michael-type genotoxin
T J Warr 1, J M Parry, R D Callander, J Ashby
Affiliations expand
PMID: 2233840
DOI: 10.1016/0165-7992(90)90049-p

Abstract


Methyl vinyl sulphone (MVS) is a labile, Michael-reactive chemical, similar in structure to acrylamide (AA). Given that acrylamide is a reference mammalian mutagen and a rodent carcinogen, studies were undertaken to evaluate the potential genotoxicity of MVS. In common with AA, MVS was non-mutagenic to Salmonella but active as an aneugen to cultured mammalian cells. It is concluded that vinyl sulphones should be regarded as representative of a new class of genotoxic chemical whose mode of action is probably primarily dependent upon Michael reactivity to proteins.
https://pubmed.ncbi.nlm.nih.gov/2233840/
Notes and references[edit]

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