. 1996 Apr;28(2):960-3.
Brequinar sodium
D V Cramer 1
Affiliations expand
PMID: 8623481
Abstract
The future use of BQR as a component of a treatment regimen for preventing graft rejection is uncertain. The drug exhibits a number of characteristics that are considered desirable for inclusion in a multidrug antirejection protocol. BQR is an effective immunosuppressive agent and can act as a single agent to prevent the rejection of allografts and xenografts. Its immunosuppressive activity is especially useful in those situations for which inhibition of antibody production is an important objective of the treatment protocol...
https://pubmed.ncbi.nlm.nih.gov/8623481/
Eur J Med Chem
. 2020 Dec 1;207:112705. doi: 10.1016/j.ejmech.2020.112705. Epub 2020 Aug 22.
Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies
Mudasir Maqbool 1, Joshna Gadhavi 2, Pravin Hivare 2, Sharad Gupta 3, Nasimul Hoda 4
Affiliations expand
PMID: 32961434
DOI: 10.1016/j.ejmech.2020.112705
https://pubmed.ncbi.nlm.nih.gov/32961434/
Curr Pharm Des
. 2013;19(8):1528-48.
Privileged scaffolds or promiscuous binders: a glance of pyrrolo[2,1-f][1,2,4]triazines and related bridgehead nitrogen heterocycles in medicinal chemistry
Yu'ning Song 1, Peng Zhan, Qingzhu Zhang, Xinyong Liu
Affiliations expand
PMID: 23131184
https://pubmed.ncbi.nlm.nih.gov/23131184/
Review
Biopolymers
. 2000;55(2):140-64.doi: 10.1002/1097-0282(2000)55:2<140::AID-BIP40>3.0.CO;2-B.
Triazine-based condensing reagents
Z J Kamiński 1
Affiliations expand
PMID: 11074411
DOI: 10.1002/1097-0282(2000)55:2<140::AID-BIP40>3.0.CO;2-B
Abstract
The synthesis, properties, and application of condensing reagents derived from 1,3,5-triazines are described. The mechanism of activation of carboxylic function, structure of reactive intermediates, and mechanism of acylation of nucleophiles are presented. The synthetic versatility of mono- and bifunctional reagents for syntheses in solution, triazine-based immobilized reagents, chiral triazines for enantiodifferentiating syntheses, are discussed. The scope and limitation of the synthetic utility of triazine reagents in the preparation of heterocyclic compounds, amides, esters, oligopeptides-including large-scale syntheses and use in the combinatorial chemistry-is demonstrated.
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Synthesis and application of chiral triazine condensing reagents prepared from esters of amino acids.
Kamiński ZJ, Zajac KJ, Jastrzabek K.Acta Biochim Pol. 2001;48(4):1143-6.PMID: 11995981
N-triazinylammonium tetrafluoroborates. A new generation of efficient coupling reagents useful for peptide synthesis.
Kamiński ZJ, Kolesińska B, Kolesińska J, Sabatino G, Chelli M, Rovero P, Błaszczyk M, Główka ML, Papini AM.J Am Chem Soc. 2005 Dec 7;127(48):16912-20. doi: 10.1021/ja054260y.PMID: 16316237
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Pharmazie
. 2001 Apr;56(4):275-86.
Chemistry of uncondensed 1,2,4-triazines, Part IV. Synthesis and chemistry of bioactive 3-amino-1,2,4-triazines and related compounds--an overview
R M Abdel-Rahman 1
Affiliations expand
PMID: 11338663
Abstract
Studies on the chemical reactivity of bioactive 3-amino-1,2,4-triazines are reviewed. The synthesis, unique features and pharmacological significance of these constituents are discussed.
https://pubmed.ncbi.nlm.nih.gov/11338663/
Molecules
. 2020 Nov 23;25(22):5475. doi: 10.3390/molecules25225475.
1,3,5-Triaryl-1,3,5-Triazinane-2,4,6-Trithiones: Synthesis, Electronic Structure and Linear Optical Properties
Ismaël Rabouel 1, Nicolas Richy 1, Anissa Amar 2 3, Abdou Boucekkine 1, Thierry Roisnel 1, Olivier Mongin 1, Mark G Humphrey 4, Frédéric Paul 1
Affiliations expand
PMID: 33238454
PMCID: PMC7700228
DOI: 10.3390/molecules25225475Free PMC article
Abstract
The synthesis of four new 1,3,5-triaryl-1,3,5-triazinane-2,4,6-trithione derivatives (thioisocyanurates) and two new partially thionated analogues from the corresponding 1,3,5-triaryl-1,3,5-triazinane-2,4,6-triones (isocyanurates) is reported, together with their spectroscopic properties. DFT calculations and comparison with the corresponding isocyanurates evidence the impact of the oxygen-for-sulfur replacement on the electronic structure and linear optical properties of these heterocycles. A bathochromic shift of the absorption bands and more efficient quenching of the fluorescence was observed.
Keywords: DFT calculations; cyclic thioureas; cyclic urea; isocyanurates; linear optics; thioisocyanurates; thionation.
https://pubmed.ncbi.nlm.nih.gov/33238454/
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Synthesis, Characterization, and Biological Evaluation of Novel 7-Oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic Acid Derivatives.
Cai D, Li T, Xie Q, Yu X, Xu W, Chen Y, Jin Z, Hu C.Molecules. 2020 Mar 13;25(6):1307. doi: 10.3390/molecules25061307.PMID: 32182992 Free PMC article.
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o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity.
Jin GF, Ban HS, Nakamura H, Lee JD.Molecules. 2018 Aug 30;23(9):2194. doi: 10.3390/molecules23092194.PMID: 30200261 PMC article.
Regioselective Fluorination of 7-Oxo-1,2,4-benzotriazines Using Selectfluor.
Mirallai SI, Koutentis PA, Aldabbagh F.Molecules. 2019 Jan 14;24(2):282. doi: 10.3390/molecules24020282.PMID: 30646524 Free PMC article.
Divinyl sulphone
- Formula: C4H6O2S
- Molecular weight: 118.154
- IUPAC Standard InChI:
- InChI=1S/C4H6O2S/c1-3-7(5,6)4-2/h3-4H,1-2H2
- Download the identifier in a file.
- IUPAC Standard InChIKey: AFOSIXZFDONLBT-UHFFFAOYSA-N
- CAS Registry Number: 77-77-0
- Chemical structure:
https://webbook.nist.gov/cgi/cbook.cgi?ID=77-77-0
Basal metabolic rate
Basal metabolic rate (BMR) is the rate of energy expenditure per unit time by endothermic animals at rest.[1] It is reported in energy units per unit time ranging from watt (joule/second) to ml O2/min or joule per hour per kg body mass J/(h·kg). Proper measurement requires a strict set of criteria be met. These criteria include being in a physically and psychologically undisturbed state, in a thermally neutral environment, while in the post-absorptive state(i.e., not actively digesting food).[1] In bradymetabolic animals, such as fish and reptiles, the equivalent term standard metabolic rate (SMR) is used. It follows the same criteria as BMR, but requires the documentation of the temperature at which the metabolic rate was measured. This makes BMR a variant of standard metabolic rate measurement that excludes the temperature data, a practice that has led to problems in defining "standard" rates of metabolism for many mammals.[1]
Metabolism comprises the processes that the body needs to function.[2] Basal metabolic rate is the amount of energy per unit of time that a person needs to keep the body functioning at rest. Some of those processes are breathing, blood circulation, controlling body temperature, cell growth, brain and nerve function, and contraction of muscles. Basal metabolic rate affects the rate that a person burns calories and ultimately whether that individual maintains, gains, or loses weight. The basal metabolic rate accounts for about 60 to 75% of the daily calorie expenditure by individuals. It is influenced by several factors. BMR typically declines by 1–2% per decade after age 20, mostly due to loss of fat-free mass,[3] although the variability between individuals is high.[4]
5. SULPHENES AS PHOTOCHEhlICAL INTERMEDIATES1
J.F.KING,P.DE ~'IAToE,.A'IORKVEDA,.~B.hl.A.SATTARA,ND A.STOESSL~ Department of Chemistry, Univeisity of Western Ontavio, London, Ontario
Received August 23, 1962
ABSTRACT
The present status of sulphenes (RIR"C:SO~)as stable entities or chemical intermediates is discussed. The early report by Locher and Fierz (Helv. Chitn. Acta, 10, 642 (1927)) of the preparation of a stable crystalline sulphene has been investigated; it is concluded that their claim is unfounded.
The irradiation of unsaturated sultones in the presence of methanol is shown to give sul- phonic esters: the corresponding thermal reaction of sultones is known to lead to sulphonic acid derivatives. It is proposed that the irradiation of unsaturated sultones yields sulphenes, which then react with the medium
https://cdnsciencepub.com/doi/pdf/10.1139/v63-012
Titanium sulphene: two-dimensional confinement of electrons and phonons giving rise to improved thermoelectric performance.
https://www.semanticscholar.org/paper/Titanium-sulphene%3A-two-dimensional-confinement-of-Zhang-Wan/959fb9c498f0ff17fc5a8571d0541aa00aaeb85b
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