08-01-2021-0221 - draft - Treatment of leprosy with diamino-diphenyl sulphone by mouth

n Tuberc Other Mycobact Dis

. 2021 May 8;24:100244. doi: 10.1016/j.jctube.2021.100244.eCollection 2021 Aug.
Approach to the diagnosis and treatment of non-tuberculous mycobacterial disease
Kelly M Pennington 1, Ann Vu 1, Douglas Challener 2, Christina G Rivera 3, F N U Shweta 2, John D Zeuli 3, Zelalem Temesgen 2
Affiliations expand
PMID: 34036184
PMCID: PMC8135042
DOI: 10.1016/j.jctube.2021.100244Free PMC article

Abstract

Non-tuberculous mycobacteria (NTM) is a collective name given to a group of more than 190 species of Mycobacterium. The clinical presentation for most NTM infections is non-specific, often resulting in delayed diagnosis. Further complicating matters is that NTM organisms can be difficult to isolate. Medications used to treat NTM infection can be difficult for patients to tolerate, and prolonged courses of anti-mycobacterial therapy are often required for adequate suppression or eradication. Herein, we review different NTM syndromes, appropriate diagnostic tests, and treatment regimens.

Keywords: ADR, adverse drug reactions; AFB, acid fast bacilli; AST, antimicrobial-susceptibility testing; ATS, American Thoracic Society; BCG, Bacille Calmette-Guerin; CLSI, Clinical and Laboratory Standards Institute; COPD, chronic obstructive pulmonary disease; ECG, electrocardiogram; EMB, ethambutol; Erm, erythromycin ribosomal methylase; FDA, Food and Drug Administration; HIV, human immunodeficiency virus; HRCT, high resolution computed tomography; IDSA, Infectious Disease Society of America; INF-γ, interferon- γ; INH, isoniazid; MAC, Mycobacterium avium complex; MALDI-TOF, matrix-assisted laser desorption ionization time-of-flight mass spectrometry; MGIT, mycobacteria growth indicator tube; MIC, minimum inhibitory concentrations; Mycobacterium abscessus; Mycobacterium avium; NTM, non-tuberculous mycobacteria; Non-tuberculous mycobacteria; PCR, polymerase chain reaction; PFT, pulmonary function test; TB, tuberculosis; TDM, therapeutic drug monitoring.

© 2021 The Authors. Published by Elsevier Ltd.

https://pubmed.ncbi.nlm.nih.gov/34036184/

Lancet

. 1950 Jan 28;1(6596):145-50. doi: 10.1016/s0140-6736(50)90257-1.
Treatment of leprosy with diamino-diphenyl sulphone by mouth
J LOWE
PMID: 15401496
DOI: 10.1016/s0140-6736(50)90257-1
No abstract available
https://pubmed.ncbi.nlm.nih.gov/15401496/