Blog Archive

Sunday, August 15, 2021

08-15-2021-0023 - Progressive osseous heteroplasia

Progressive osseous heteroplasia

From Wikipedia, the free encyclopedia
Jump to navigationJump to search
Progressive osseous heteroplasia
SpecialtyDermatology

Progressive osseous heteroplasia is a cutaneous condition characterized by cutaneous or subcutaneous ossification.[1]

According to the Progressive Osseous Heteroplasia Association:

Progressive Osseous Heteroplasia (POH) is a rare genetic condition in which the body makes extra bone in locations where bone should not form. Extra bone develops inside skin, subcutaneous tissue (fat tissue beneath the skin), muscles, tendons, and ligaments. This ”out of place extra bone formation” is commonly referred to as heterotopic ossification. In people with POH, nodules and lace-like webs of extra bone extend from the skin into the subcutaneous fat and deep connective tissues, and may cross joints. Extra bone formation near the joints may lead to stiffness, locking, and permanent immobility.”[2]

It is associated with GNAS.[3]

See also[edit]

References[edit]

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ "About POH Disease". Retrieved 2012-06-15.
  3. ^ Adegbite NS, Xu M, Kaplan FS, Shore EM, Pignolo RJ (July 2008). "Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification"Am. J. Med. Genet. A146A (14): 1788–96. doi:10.1002/ajmg.a.32346PMC 2564798PMID 18553568.

External links[edit]

Classification


Categories: 

 https://en.wikipedia.org/wiki/Progressive_osseous_heteroplasia



No comments:

Post a Comment