Protein misfolding cyclic amplification (PMCA) is an amplification technique (conceptually like PCR but not involving nucleotides) to multiply misfolded prions originally developed by Soto and colleagues.[1] It is a test for spongiform encephalopathies like CWD[2] or BSE.
https://en.wikipedia.org/wiki/Protein_misfolding_cyclic_amplification
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