SAPHO syndrome includes a variety of inflammatory bone disorders that may be associated with skin changes. These diseases share some clinical, radiologic, and pathologic characteristics.
An entity initially known as chronic recurrent multifocal osteomyelitis was first described in 1972.[1]Subsequently, in 1978,[2] several cases of were associated with blisters on the palms and soles (palmoplantar pustulosis). Since then, a number of associations between skin conditions and osteoarticular disorders have been reported under a variety of names, including sternocostoclavicular hyperostosis, pustulotic arthro-osteitis, and acne-associated spondyloarthropathy. The term SAPHO (an acronym for synovitis, acne, pustulosis, hyperostosis, osteitis) was coined in 1987[3] to represent this spectrum of inflammatory bone disorders that may or may not be associated with dermatologic pathology.
| SAPHO syndrome | |
|---|---|
| Other names | Synovitis-acne-pustulosis-hyperostosis-osteitis syndrome |
| Specialty | Rheumatology |
https://en.wikipedia.org/wiki/SAPHO_syndrome
Opportunistic diseases[edit]
C. acnes is often considered an opportunistic pathogen, causing a range of postoperative and device-related infections e.g., surgical infections,[25] post-neurosurgical infections,[26] infected joint prostheses (especially shoulder),[27] neurosurgical shunt infections and endocarditis in patients with prosthetic heart valves (predominantly men).[28] C. acnes may play a role in other conditions, including SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, sarcoidosis and sciatica.[29] It is also suspected a main bacterial source of neuroinflammation in Alzheimer's disease brains.[30] It is a common contaminant in blood and cerebrospinal fluid cultures.[31][32]
https://en.wikipedia.org/wiki/Cutibacterium_acnes
Helicobacter pylori colonizes the human stomach and duodenum. In some cases it can cause stomach cancer[3][4] and MALT lymphoma.[5] Animal models have demonstrated Koch's third and fourth postulates for the role of Helicobacter pylori in the causation of stomach cancer.[6] The mechanism by which H. pylori causes cancer may involve chronic inflammation, or the direct action of some of its virulence factors, for example, CagA has been implicated in carcinogenesis.[7]
https://en.wikipedia.org/wiki/Carcinogenic_bacteria
08-30-2021-1916 - SAPHO syndrome inflammatory bone disease synovitis, acne, pustulosis, hyperostosis, osteitis; opportunistic disease and cystulant Cutibacterium acnes actinoform - helicobacter pylori H. pylori causes cancer may involve chronic inflammation, or the direct action of some of its virulence factors, for example, CagA has been implicated in carcinogenesis.[7] - CANCER
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