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Tuesday, May 9, 2023

05-09-2023-1524 - Humoral immune deficiencies

Humoral immune deficiencies are conditions which cause impairment of humoral immunity, which can lead to immunodeficiency. It can be mediated by insufficient number or function of B cells, the plasma cells they differentiate into, or the antibody secreted by the plasma cells.[7] The most common such immunodeficiency is inherited selective IgA deficiency, occurring between 1 in 100 and 1 in 1000 persons, depending on population. They are associated with increased vulnerability to infection, but can be difficult to detect (or asymptomatic) in the absence of infection.[citation needed] 

Humoral immune deficiency
Original antigenic sin.svg
B cells and antibody
SpecialtyHematology 
SymptomsSinusitis[1]
CausesAbsent B cells(primary),[2][3] Multiple myeloma(secondary)[4]
Diagnostic methodB cell count, Family medical history[5][6]
TreatmentImmunoglobulin replacement therapy[5]

Causes

Cause of this deficiency is divided into primary and secondary:

Hyper-IgM syndromes(immunoglobulin M)
  • Secondary secondary (or acquired) forms of humoral immune deficiency are mainly due to hematopoietic malignancies and infections that disrupt the immune system:[4]

Diagnosis

Human B cell

In terms of diagnosis of humoral immune deficiency depends upon the following:[5][6]

Treatment

Treatment for B cell deficiency (humoral immune deficiency) depends on the cause, however generally the following applies:[5]

See also

 

https://en.wikipedia.org/wiki/Humoral_immune_deficiency



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