BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Rafand v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf.[5][6]
The B-Raf protein is involved in sending signals inside cells which are involved in directing cell growth. In 2002, it was shown to be mutated in some human cancers.[7]
Certain other inherited BRAF mutations cause birth defects.
Drugs that treat cancers driven by BRAF mutations have been developed. Two of these drugs, vemurafenib[8] and dabrafenib are approved by FDA for treatment of late-stage melanoma. Vemurafenib was the first approved drug to come out of fragment-based drug discovery.[9]
https://en.wikipedia.org/wiki/BRAF_(gene)#BRAF_inhibitors_in_the_clinic
No comments:
Post a Comment