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Monday, August 23, 2021

08-23-2021-0922 - Ground squirrel hepatitis virus

Ground squirrel hepatitis virus, abbreviated GSHV, is a partially double-stranded DNA virus that is closely related to human Hepatitis B virus (HBV) and Woodchuck hepatitis virus (WHV).[1] It is a member of the family of viruses Hepadnaviridae and the genus Orthohepadnavirus.[2] Like the other members of its family, GSHV has high degree of species and tissue specificity.[3] It was discovered in Beechey ground squirrelsSpermophilus beecheyi, but also infects Arctic ground squirrelsSpermophilus parryi.[1][2] Commonalities between GSHV and HBV include morphology, DNA polymerase activity in genome repair, cross-reacting viral antigens, and the resulting persistent infection with viral antigen in the blood (antigenemia).[4] As a result, GSHV is used as an experimental model for HBV.[5] 

https://en.wikipedia.org/wiki/Ground_squirrel_hepatitis_virus




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