Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide(NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1(solute carrier family 10 member 1) gene.[5][6]
Sodium/bile acid cotransporters are integral membrane glycoproteins. Human NTCP contains 349 amino acids and has a mass of 56 kDa.[7]
Individuals that lack functional NTCP have been identified.[10] These individuals display highly elevated bile salt levels in plasma, but without a clear phenotype. In areas of the world with a high prevalence of HBV, there are multiple individuals who carry the NTCP p.S267F polymorphism on both alleles; this makes NTCP inactive as a bile acid transporter, but provides protection against HBV infection.[11]
NTCP-deficient mice have also been created. These mice have reduced hepatic bile salt uptake but plasma bile salt levels are less clearly elevated, as the rodent-specific OATP1a/1b transporters provide can partially replace the function of NTCP.[12] Nevertheless, this NTCP-knockout animal model pointed to possible additional (non-HBV) aspects of NTCP-deficiency. NTCP-deficient mice are partially protected against the problems associated with a high-calorie diet, including excessive weight gain[13] and to liver damage in cholestasis.[14] These effects of NTCP deficiency have not yet been replicated in humans.
https://en.wikipedia.org/wiki/Sodium/bile_acid_cotransporter
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