Ravn virus (/ˈrævən/;[1] RAVV) is a close relative of the much more commonly known Marburg virus (MARV). RAVV causes Marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever.[2] RAVV is a Select agent,[3] World Health Organization Risk Group 4 Pathogen (requiring Biosafety Level 4-equivalent containment),[4] National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogen,[5] Centers for Disease Control and Prevention Category A Bioterrorism Agent,[6] and listed as a Biological Agent for Export Control by the Australia Group.[7]
Ravn virus was first introduced as a new subtype of Marburg virus in 1996.[8] In 2006, a whole-genome analysis of all marburgviruses revealed the existence of five distinct genetic lineages. The genomes of representative isolates of four of those lineages differed from each other by only 0-7.8% on the nucleotide level, whereas representatives of the fifth lineage, including the new "subtype", differed from those of the other lineages by up to 21.3%.[9] Consequently, the fifth genetic lineage was reclassified as a virus, Ravn virus (RAVV), distinct from the virus represented by the four more closely related lineages, Marburg virus (MARV).[1]
Further reading[edit]
- Klenk, Hans-Dieter (1999), Marburg and Ebola Viruses. Current Topics in Microbiology and Immunology, vol. 235, Berlin, Germany: Springer-Verlag, ISBN 978-3-540-64729-4
- Klenk, Hans-Dieter; Feldmann, Heinz (2004), Ebola and Marburg Viruses - Molecular and Cellular Biology, Wymondham, Norfolk, UK: Horizon Bioscience, ISBN 978-0-9545232-3-7
- Kuhn, Jens H. (2008), Filoviruses - A Compendium of 40 Years of Epidemiological, Clinical, and Laboratory Studies. Archives of Virology Supplement, vol. 20, Vienna, Austria: SpringerWienNewYork, ISBN 978-3-211-20670-6
- Martini, G. A.; Siegert, R. (1971). Marburg Virus Disease. Berlin, Germany: Springer-Verlag. ISBN 978-0-387-05199-4.
- Ryabchikova, Elena I.; Price, Barbara B. (2004), Ebola and Marburg Viruses - A View of Infection Using Electron Microscopy, Columbus, Ohio, USA: Battelle Press, ISBN 978-1-57477-131-2
https://en.wikipedia.org/wiki/Ravn_virus
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