Oxazole is the parent compound for a vast class of heterocyclic aromatic organic compounds. These are azoles with an oxygen and a nitrogen separated by one carbon.[3] Oxazoles are aromatic compounds but less so than the thiazoles. Oxazole is a weak base; its conjugate acid has a pKa of 0.8, compared to 7 for imidazole.
Classical oxazole synthetic methods in organic chemistry are
- the Robinson–Gabriel synthesis by dehydration of 2-acylaminoketones
- the Fischer oxazole synthesis from cyanohydrins and aldehydes
- the Bredereck reaction with α-haloketones and formamide
- the Van Leusen reaction with aldehydes and TosMIC
https://en.wikipedia.org/wiki/Oxazole
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