09-18-2021-0818 - Ligand Cone Angle Tolman Cone Angle ligand cone angle Tolman cone angle tolman cone angle

The ligand cone angle (a common example being the Tolman cone angle or θ) is a measure of the steric bulk of a ligand in a transition metal complex. It is defined as the solid angle formed with the metal at the vertex and the outermost edge of the van der Waals spheres of the ligand atoms at the perimeter of the cone (see figure). Tertiary phosphine ligands are commonly classified using this parameter, but the method can be applied to any ligand. The term cone angle was first introduced by Chadwick A. Tolman, a research chemist at DuPont. Tolman originally developed the method for phosphine ligands in nickel complexes, determining them from measurements of accurate physical models.^[1][2][3]

Asymmetric cases[edit]

The concept of cone angle is most easily visualized with symmetrical ligands, e.g. PR₃. But the approach has been refined to include less symmetrical ligands of the type PRR′R″ as well as diphosphines. In such asymmetric cases, the substituent angles' half angles, θ_i/2, are averaged and then doubled to find the total cone angle, θ. In the case of diphosphines, the θ_i/2 of the backbone is approximated as half the chelate bite angle, assuming a bite angle of 74°, 85°, and 90° for diphosphines with methylene, ethylene, and propylene backbones, respectively. The Manz cone angle is often easier to compute than the Tolman cone angle:^[4]

Cone angles of common phosphine ligands

Ligand	Angle (°)
PH3	87[1]
PF3	104[1]
P(OCH3)3	107[1]
dmpe	107
depe	115
P(CH3)3	118[1]
dppm	121
dppe	125
dppp	127
P(CH2CH3)3	132[1]
dcpe	142
P(C6H5)3	145[1]
P(cyclo-C6H11)3	179[1]
P(t-Bu)3	182[1]
P(C6F5)3	184[1]
P(C6H4-2-CH3)3	194[1]
P(2,4,6-Me3C6H2)3	212

Variations[edit]

The Tolman cone angle method assumes empirical bond data and defines the perimeter as the maximum possible circumscription of an idealized free-spinning substituent. The metal-ligand bond length in the Tolman model was determined empirically from crystal structures of tetrahedral nickel complexes. In contrast, the solid-angle concept derives both bond length and the perimeter from empirical solid state crystal structures.^[5][6] There are advantages to each system.

If the geometry of a ligand is known, either through crystallography or computations, an exact cone angle (θ) can be calculated.^[7][8][9] No assumptions about the geometry are made, unlike the Tolman method.

Application[edit]

The concept of cone angle is of practical importance in homogeneous catalysis because the size of the ligand affects the reactivity of the attached metal center. In an^[10] example, the selectivity of hydroformylation catalysts is strongly influenced by the size of the coligands. Despite being monovalent, some phosphines are large enough to occupy more than half of the coordination sphere of a metal center.

See also[edit]

• Bite angle
• Steric effects (versus electronic effects)
• Tolman electronic parameter

https://en.wikipedia.org/wiki/Ligand_cone_angle

Categories: 

• Tertiary phosphines
• Stereochemistry
• Organometallic chemistry
• Coordination chemistry

https://en.wikipedia.org/wiki/Tolman_electronic_parameter