08-28-2021-114308-
lipodystrophy
lipopolysaccharide bacteria
bacillus thurigiensis, hormones, methroxetrate - insects, crops food, water treatment, etc..
crusteceans (sea water america; hygroscopants)
cell expansion bacterial colonization micro colony
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08-28-2021-1143
Primer (homeostasis/etc.; systemic compromise etc.): Innoculation (system), Infection (system), Insectitazation Insectization Insectazation (Surroundings, environment)
Catch (cell first target; processes/directionality/outcome/rate/equilibrium/etc.): Virus
Focal Focalized Regional (organ second target): Liver, Thymus, Neck, Spleen.
Disseminated Systemic (system third target; immunocompromise with jump the gun; alternate time schedule - petersen/USA/Americas/etc.): Cancer Methroxetrate
Damage (malacia, dysplasia, holeing, moleing, caviation; biofilm plaque tartar calculus mineralization lieuqfication/liquefication): brain eye spine bone
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Not usually evidenced by young persons; persons of general hygiene/good health/good genetics/natural immunity-acquired/etc.. Not precondition to weight change, etc.. Not all expanded cells are bacterial colonized/infected/etc. (esp. in era of physics, nuclear operations, etc.). Chemical non-biological may influence gene expression without infection/infectious disease/horizontal transmission/vertical transmission/etc.. Pharmaceutical cause sometimes, including reaction or hyperreaction to progesterone, glycoside, glycoproteins, lipid reduction pharmaceuticals, hormones, anabolic substance, statin, steroid, anti-neoplasic agent, etc..
Neurosarcoidosis, once confirmed, is generally treated with glucocorticoids such as prednisolone. If this is effective, the dose may gradually be reduced (although many patients need to remain on steroids long-term, frequently leading to side-effects such as diabetes or osteoporosis). Methotrexate, hydroxychloroquine, cyclophosphamide, pentoxifylline, thalidomide and infliximab have been reported to be effective in small studies. In patients unresponsive to medical treatment, radiotherapy may be required. If the granulomatous tissue causes obstruction or mass effect, neurosurgicalintervention is sometimes necessary. Seizures can be prevented with anticonvulsants, and psychiatric phenomena may be treated with medication usually employed in these situations.[1]
https://en.wikipedia.org/wiki/Neurosarcoidosis
Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 5×108/L (500/μL).[1] Hypereosinophilia is an elevation in an individual's circulating blood eosinophil count above 1.5 x 109/L (i.e. 1,500/μL). The hypereosinophilic syndrome is a sustained elevation in this count above 1.5 x 109/L (i.e. 1,500/μL) that is also associated with evidence of eosinophil-based tissue injury.
Eosinophils are one form of terminally differentiated granulocytes; they function to neutralize invading microbes, primarily parasites and helminthes but also certain types of fungi and viruses.
They also participate in transplant rejection, Graft-versus-host disease, and the killing of tumor cells.
In conducting these functions, eosinophils produce and release on demand a range of toxic reactive oxygen species (e.g. hypobromite, hypobromous acid, superoxide, and peroxide) and they also release on demand a preformed armamentarium of cytokines, chemokines, growth factors, lipid mediators (e.g. leukotrienes, prostaglandins, platelet activating factor), and toxic proteins (e.g. metalloproteinases, major basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived neurotoxin).
https://en.wikipedia.org/wiki/Eosinophilia
The exact cause of sarcoidosis is not known.[2] The current working hypothesis is, in genetically susceptible individuals, sarcoidosis is caused through alteration to the immune response after exposure to an environmental, occupational, or infectious agent.[74] Some cases may be caused by treatment with tumor necrosis factor (TNF) inhibitors like etanercept.[75]
Genetics[edit]
The heritability of sarcoidosis varies according to ethnicity. About 20% of African Americans with sarcoidosis have a family member with the condition, whereas the same figure for European Americans is about 5%. Additionally, in African Americans, who seem to experience more severe and chronic disease, siblings and parents of sarcoidosis cases have about a 2.5-fold increased risk for developing the disease.[26] In Swedish individuals heritability was found to be 39%.[76] In this group, if a first-degree family member was affected, a person has a four-fold greater risk of being affected.[76]
Investigations of genetic susceptibility yielded many candidate genes, but only few were confirmed by further investigations and no reliable genetic markers are known. Currently, the most interesting candidate gene is BTNL2; several HLA-DR risk alleles are also being investigated.[77][78] In persistent sarcoidosis, the HLA haplotype HLA-B7-DR15 is either cooperating in disease or another gene between these two loci is associated. In nonpersistent disease, a strong genetic association exists with HLA DR3-DQ2.[79][80] Cardiac sarcoid has been connected to tumor necrosis factor alpha (TNFA) variants.[81]
Infectious agents[edit]
Several infectious agents appear to be significantly associated with sarcoidosis, but none of the known associations is specific enough to suggest a direct causative role.[82] The major implicated infectious agents include: mycobacteria, fungi, borrelia, and rickettsia.[83] A meta-analysis investigating the role of mycobacteria in sarcoidosis found it was present in 26.4% of cases, but they also detected a possible publication bias, so the results need further confirmation.[84][85] Mycobacterium tuberculosis catalase-peroxidase has been identified as a possible antigen catalyst of sarcoidosis.[86] The disease has also been reported by transmission via organ transplants.[87] A large epidemiological study found little evidence that infectious diseases spanning years before sarcoidosis diagnosis could confer measurable risks for sarcoidosis diagnosis in the future.[88]
https://en.wikipedia.org/wiki/Sarcoidosis
1 - https://en.wikipedia.org/wiki/Bovine_gammaherpesvirus_4
2 - https://en.wikipedia.org/wiki/Mu-rid_gammaherpesvirus_4
3 - https://en.wikipedia.org/wiki/Alloherpesviridae
4 - https://en.wikipedia.org/wiki/Malacoherpesviridae
5 - https://en.wikipedia.org/wiki/Ostreavirus
6 - https://en.wikipedia.org/wiki/Batrachovirus
7 - https://en.wikipedia.org/wiki/Cyprinivirus
8 - https://en.wikipedia.org/wiki/Ictalurivirus
9 - https://en.wikipedia.org/wiki/Salmonivirus
10 - https://en.wikipedia.org/wiki/Iltovirus
11 - https://en.wikipedia.org/wiki/Roseolovirus
Salmonivirus is a genus of viruses in the order Herpesvirales, in the family Alloherpesviridae. Salmonidae serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: salHV-3: epizootic epitheliotropic disease.[1][2]
https://en.wikipedia.org/wiki/Salmonivirus
Batrachovirus is a genus of viruses in the order Herpesvirales, in the family Alloherpesviridae. Frogs serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: raHV-1: Lucké tumor (renal adenocarcinoma).[1][2]
https://en.wikipedia.org/wiki/Batrachovirus
Ostreavirus is a genus of viruses in the order Herpesvirales, and one of only two genera in the family Malacoherpesviridae. Molluscs serve as natural hosts. There is only one species described in this genus, Ostreid herpesvirus 1 (OsHV-1), commonly known as oyster herpesvirus. A disease associated with this genus is sporadic episodes of high mortality among larvae and juveniles.[1][2]
Acute viral necrosis virus, which affects scallops such as Chlamys farreri, appears to be a variant of Ostreid herpesvirus 1.[3]
Ostreid herpesvirus 1 was subsequently detected in the common octopus (Octopus vulgaris).[4]
https://en.wikipedia.org/wiki/Ostreavirus
Lymphocryptovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. This genus includes the human-infecting Human gammaherpesvirus 4 (Epstein–Barr virus), as well as viruses that infect both Old World monkeys and New World monkeys.[2] Other names for the Lymphocryptovirus genus include Lymphocryptoviridae (suffix -viridae implying family rank, although this is not the accepted taxonomy) and gamma-1 herpesviruses. There are nine species in this genus. Diseases associated with this genus include: mononucleosis, Burkitt's lymphoma, and nasopharyngeal carcinoma.[3][4]
https://en.wikipedia.org/wiki/Lymphocryptovirus
Percavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: conjunctivitis, immunosuppression in foals, pneumonia, respiratory disease.[1][2]
https://en.wikipedia.org/wiki/Percavirus
Ranid herpesvirus 1 (RaHV-1), also known as the Lucké tumor herpesvirus (LTHV), is a double-stranded DNAvirus within the order Herpesvirales.[1][2][3][4] The virus was initially observed within renal tumors in 1934 by Baldwin Lucké, and more recently has become identifiable through the use of PCR in samples isolated from frog tumors. RaHV-1 causes renal tumors within the northern leopard frog, Rana pipiens. The virus has not yet been isolated in vitro within cell lines, meaning that while its existence and symptoms are fairly evident, its methods of transmission, cell infection, and reproduction are largely unknown.[5]
Since it has not been cultured in vitro, temporal studies regarding the kinetics of virus growth and biological and molecular events in the replication cycle have not been undergone extensively. Ranid herpesvirus 1, along with Ranid herpesvirus 2 and 3, are the only herpes viruses known to infect amphibians.[6]
https://en.wikipedia.org/wiki/Ranid_herpesvirus_1
Macacine gammaherpesvirus 10 (McHV-10) is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]
https://en.wikipedia.org/wiki/Macacine_gammaherpesvirus_10
Felid gammaherpesvirus 1 (FeHV-1) is a species of virus in the genus Percavirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]
https://en.wikipedia.org/wiki/Felid_gammaherpesvirus_1
Saimiriine gammaherpesvirus 2 (SaHV-2) is a species of virus in the genus Rhadinovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]
https://en.wikipedia.org/wiki/Saimiriine_gammaherpesvirus_2
Human alphaherpesvirus 3 (HHV-3), usually referred to as the varicella-zoster virus (VZV), is one of nine herpesviruses known to infect humans. It causes pox chickenpox (varicella), a disease most commonly affecting children, teens, and young adults, and shingles (herpes zoster) in adults; shingles is rare in children. VZV infections are species-specific to humans, but can survive in external environments for a few hours.[3]
VZV multiplies in the lungs, and causes a wide variety of symptoms. After the primary infection (chickenpox), the virus lies dormant in the nerves, including the cranial nerve ganglia, dorsal root ganglia, and autonomic ganglia. Many years after the person has recovered from chickenpox, VZV can reactivate to cause neurological conditions.[4]
https://en.wikipedia.org/wiki/Varicella_zoster_virus
Spheniscid alphaherpesvirus 1 (SpAHV-1) is a species of virus in the genus Mardivirus, subfamily Alphaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]
https://en.wikipedia.org/wiki/Spheniscid_alphaherpesvirus_1
Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. HHV-6B infects nearly 100% of human beings, typically before the age of three and often results in fever, diarrhea, sometimes with a rash known as roseola. Although rare, this initial infection HHV-6B infection can also cause febrile seizures, encephalitis or intractable seizures. Little is known about the prevalence of HHV-6A or how it is acquired, but one small study found very low levels of HHV-6A in the saliva of half of healthy adults.
https://hhv-6foundation.org/what-is-hhv-6
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