SNARE proteins – "SNAP REceptor" – are a large protein familyconsisting of at least 24 members in yeasts and more than 60 members in mammalian cells.[2][3] The primary role of SNARE proteins is to mediate vesicle fusion – the fusion of vesicles with the target membrane; this notably mediates exocytosis, but can also mediate the fusion of vesicles with membrane-bound compartments (such as a lysosome). The best studied SNAREs are those that mediate the neurotransmitter release of synaptic vesicles in neurons. These neuronal SNAREs are the targets of the neurotoxinsresponsible for botulism and tetanus produced by certain bacteria.
Molecular machinery driving vesicle fusion in neuromediator release. The core SNARE complex is formed by four α-helices contributed by synaptobrevin, syntaxin and SNAP-25, synaptotagmin serves as a calcium sensor and closely regulates the SNARE zipping.[1]
https://en.wikipedia.org/wiki/SNARE_(protein)
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