09-14-2021-0409 - SAR1A SAR Sar1 Yeast Mammalian Dr. Bettey Protein involved in membrane trafficking monomeric small GTPase COPII vesicles regulation assembly and disassembly of COPII coating coats Sec sec hydrophobic GDP GTP ARF Dogs Genes on human chromosome 10

 SAR1A (mammalian name) or Sar1 (yeast name) is a protein involved in membrane trafficking. It is a monomeric small GTPase found in COPII vesicles. It regulates the assembly and disassembly of COPII coats.

[GDP]-bound Sar1 interacts with the membrane-bound exchange factor Sec12 and exchanges its bound GDP for GTP. The hydrophobic N-terminusof Sar1-GTP then locates it to the membrane, where it serves as the binding site for the Sec23/Sec24 protein coat complex. After the vesicle coat is completely assembled and the vesicle is released from the donor membrane, the Sec23 subunit promotes Sar1 GTPase activity, which triggers the disassembly of the COPII coat.

See also[edit]

• ARF

https://en.wikipedia.org/wiki/SAR1A

Categories: Genes on human chromosome 10 BiomoleculesBiochemistry stubs