09-14-2021-0354 - Vesicle associated membrane proteins (VAMP) family of SNARE proteins

Vesicle associated membrane proteins (VAMP) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.

• VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neurotransmitter release.
• VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.
• VAMP5 and VAMP7 (SYBL1) participate in constitutive exocytosis.
  • VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
  • VAMP7 is found both in secretory granules and endosomes.
• VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
• VAMP4 is involved in transport from the Golgi.^[1]

Synaptobrevin
Three different views of the high resolution structure of a truncated neuronal SNARE complex. Legend: synaptobrevin-2 (red), Syntaxin-1 (pink), SNAP-25 (purple).

https://en.wikipedia.org/wiki/Vesicle-associated_membrane_protein

 Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)

showvte

Membrane protein: vesicular transport proteins (TC 1F)

showvte

Acetylcholine metabolism and transport modulators

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE

SNAP25 SNAP29

Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19

Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6

R-SNARE

Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Synaptotagmin

SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT8 SYT9 SYT10 SYT11 SYT12 SYT13 SYT14 SYT15 SYT16 SYT17

Other

Synaptophysin Synapsin

Small GTPase: RAB3A

COPI

Coatomer COPA COPB1 COPB2 COPD/Archain COPE COPG COPG2 COPZ1 COPZ2

Small GTPase: ARF

COPII

Coatomer SEC23A/SEC24A SEC13/SEC31

Small GTPase: SAR1A

RME/Clathrin

CLTA CLTB CLTC

Caveolae

Caveolin (CAV1 CAV2 CAV3)

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:

AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3

Adaptor protein complex 2:

AP2A1 AP2A2 AP2B1 AP2M1 AP2S1

Adaptor protein complex 3:

AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2

Adaptor protein complex 4:

AP4B1 AP4E1 AP4M1 AP4S1

LMAN1

LYST

BLOC-1:

DTNBP1 BLOC153

BLOC-2:

HPS3 HPS5 HPS6

BLOC-3:

HPS1 HPS4

Coats:

Retromer TIP47

Small GTPase

Dynamin DNM1 DNM2 DNM3

Other

EHD protein family: EHD1 EHD2 EHD3 EHD4

Sorting nexins

Vacuolar protein sorting: VPS13B VPS33B

SYNRG

See also vesicular transport protein disorders