External links[edit]
Tumor+Suppressor+Protein+p14ARF at the US National Library of Medicine Medical Subject Headings (MeSH)
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Tumor suppressor genes and Oncogenes
Ligand
Growth factors
ONCO
c-Sis/PDGF HGF
Receptor
Wnt signaling pathway
TSP
CDH1
Hedgehog signaling pathway
TSP
PTCH1
TGF beta signaling pathway
TSP
TGF beta receptor 2
Receptor tyrosine kinase
ONCO
ErbB/c-ErbB HER2/neu Her 3 c-Met c-Ret
JAK-STAT signaling pathway
ONCO
c-Kit Flt3
Intracellular signaling P+Ps
Wnt signaling pathway
ONCO
Beta-catenin
TSP
APC
TGF beta signaling pathway
TSP
SMAD2 SMAD4
Akt/PKB signaling pathway
ONCO
c-Akt
TSP
PTEN
Hippo signaling pathway
TSP
Neurofibromin 2/Merlin
MAPK/ERK pathway
ONCO
c-Ras HRAS c-Raf
TSP
Neurofibromin 1
Other/unknown
ONCO
c-Src
TSP
Maspin
Nucleus
Cell cycle
ONCO
CDK4 Cyclin D Cyclin E
TSP
p53 pRb WT1 p16/p14arf
DNA repair/Fanconi
TSP
BRCA1 BRCA2
Ubiquitin ligase
ONCO
CBL MDM2
TSP
VHL
Transcription factor
ONCO
AP-1 c-Fos c-Jun c-Myc
TSP
KLF6
Mitochondrion
Apoptosis inhibitor
SDHB SDHD
Other/ungrouped
c-Bcl-2 Notch Stathmin
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Cell cycle proteins
Cyclin
A (A1, A2) B (B1, B2, B3) D (D1, D2, D3) E (E1, E2)
CDK
1 2 3 4 5 6 7 8 9 10 CDK-activating kinase
CDK inhibitor
INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57)
P53 p63 p73 family
p53 p63 p73
Other
Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor Wee Cullin (CUL7)
Phases and
checkpoints
Interphase
G1 phase S phase G2 phase
M phase
Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis
Cell cycle checkpoints
Restriction point Spindle checkpoint Postreplication checkpoint
Other cellular phases
Apoptosis G0 phase Meiosis
Categories: Genes on human chromosome 9
https://en.wikipedia.org/wiki/P14arf
Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin
SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A
MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin
Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant
Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin
TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped
Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders
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Membrane protein: vesicular transport proteins (TC 1F)
Synaptic vesicle
SNARE
Q-SNARE
SNAP25 SNAP29
Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19
Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE
Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3
Synaptotagmin
SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT8 SYT9 SYT10 SYT11 SYT12 SYT13 SYT14 SYT15 SYT16 SYT17
Other
Synaptophysin Synapsin
Small GTPase: RAB3A
COPI
Coatomer COPA COPB1 COPB2 COPD/Archain COPE COPG COPG2 COPZ1 COPZ2
Small GTPase: ARF
COPII
Coatomer SEC23A/SEC24A SEC13/SEC31
Small GTPase: SAR1A
RME/Clathrin
CLTA CLTB CLTC
Caveolae
Caveolin (CAV1 CAV2 CAV3)
Other/ungrouped
Vesicle formation
Adaptor protein complex 1:
AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:
AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:
AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:
AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:
DTNBP1 BLOC153
BLOC-2:
HPS3 HPS5 HPS6
BLOC-3:
HPS1 HPS4
Coats:
Retromer TIP47
Small GTPase
Dynamin DNM1 DNM2 DNM3
Other
EHD protein family: EHD1 EHD2 EHD3 EHD4
Sorting nexins
Vacuolar protein sorting: VPS13B VPS33B
SYNRG
See also vesicular transport protein disorders
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Acetylcholine metabolism and transport modulators
Enzyme
(modulators)
ChAT
Inhibitors: 1-(-Benzoylethyl)pyridinium 2-(α-Naphthoyl)ethyltrimethylammonium 3-Chloro-4-stillbazole 4-(1-Naphthylvinyl)pyridine Acetylseco hemicholinium-3 Acryloylcholine AF64A B115 BETA CM-54,903 N,N-Dimethylaminoethylacrylate N,N-Dimethylaminoethylchloroacetate
AChE
Inhibitors: Reversible: Carbamates: Aldicarb Aminocarb Bendiocarb Bufencarb Carbaryl Carbendazim Carbetamide Carbofuran Carbosulfan Chlorbufam Chloropropham Dimetilan Ethienocarb Ethiofencarb Fenobucarb Formetanate Formparanate Methiocarb Methomyl Metolcarb Miotine Oxamyl Phenmedipham Pinmicarb Pirimicarb Promecarb Propamocarb Propham Propoxur Thiodicarb Thiofanox; Stigmines: Distigmine Eptastigmine Ganstigmine Neostigmine Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride Ladostigil Minaprine Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide) T-1123 TL-599 TL-1238 Tacrine Zanapezil
Irreversible: Organophosphates: 2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate Acephate Armine Azinphos-ethyl Azinphos-methyl BAY-29952 Bensulide Cadusafos Carbophenothion Chlorethoxyfos Chlorfenvinphos Chlorpyrifos Chlorpyrifos-methyl Coumaphos Crotylsarin Cyanophos Cyclosarin (GF) Demephion Demeton Demeton-S-methyl Dialifor Diazinon Dichlorvos Dicrotophos Diisopropylphosphate Dimefox Dimethoate Dimethyl 4-(methylthio)phenyl phosphate Dioxathion Disulfoton EA-2012 EA-2054 EA-2098 EA-2192 EA-2613 EA-3148 EA-4352 Echothiophate Ethylsarin (GE) Endothion EPN Ethion Ethoprop Fenamiphos Fenitrothion Fenthion Fluorotabun Fonofos Formothion Fosthiazate GD-42 GH GT-45 GV Guanitoxin Hexaethyl tetraphosphate (HETP) Isofluorophate Isoxathion Leptophos Malaoxon Malathion Mazidox Methamidophos Methidathion Methyl phenkapton Methylfluorophosphonylcholine (MFPCh) Metrifonate Mevinphos Mipafox Monocrotophos Naled Novichok agent Omethoate Oxydemeton-methyl Paraoxon Parathion Parathion-methyl Phorate Phosalone Phosfolan Phosmet Phosphamidon Phoxim Pirimiphos-methyl Profenofos Prothoate R-16661 Ro 3-0340 Ro 3-0346 Ro 3-0347 Ro 3-0351 Ro 3-0352 Ro 3-0397 Ro 3-0411 Ro 3-0412 Ro 3-0417 Ro 3-0419 Ro 3-0422 Ro 3-0433 Ronnel Sarin (GB) Schradan Soman (GD) Sulfotep (TEDP) Tabun (GA) Tebupirimfos Temefos Terbufos Tetrachlorvinphos Tetraethyl pyrophosphate (TEPP) Triazofos Tribufos Trichlorfon Trichloronate Tricresyl phosphate VE VG VM VP VS VR VX; Others: Demecarium Fasciculins (green mamba toxins) (1, 2, 3, 4) Onchidal (Onchidella binneyi) Methanesulfonyl fluoride
Unsorted: α-Pinene α-Viniferin Affinine Affinisine Arisugacin A Bulbocapnine Conodurine Coronaridine Corydaline Corynoline Crimidine Cyclanoline Cymserine Harmaline Kobophenol A Lactucopicrin Lycorine Phosacetim Rosmarinic acid Stercuronium iodide Taspine Tetrahydrocannabinol Ungeremine Ungiminorine Dimethylcarbamoyl fluoride BW284C51 TMTFA
Reactivators: Asoxime chloride Methoxime Obidoxime Pralidoxime Trimedoxime bromide
BChE
Inhibitors: Affinine Affinisine Conodurine Cymserine Ladostigil Profenamine (ethopropazine) Rivastigmine Tacrine ZINC-12613047 Many of the other AChE inhibitors listed above
Transporter
(modulators)
CHT
Inhibitors: Hemicholinium-3 (hemicholine) Triethylcholine
Enhancers: Coluracetam
VAChT
Inhibitors: Vesamicol
Release
(modulators)
Inhibitors
SNAP-25 inactivators: Botulinum toxin (A, C, E)
VAMP inactivators: Botulinum toxin (B, D, F, G)
Others: Bungarotoxins (β-bungarotoxin, γ-bungarotoxin)
Enhancers
LPHN agonists: α-Latrotoxin
Others: Atracotoxins (e.g., robustoxin, versutoxin) Crotoxin
See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine receptor modulators
Stub icon
This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
Categories: Membrane proteinsMembrane protein stubs
https://en.wikipedia.org/wiki/Vesicle-associated_membrane_protein
External links[edit]
Synaptobrevin at the US National Library of Medicine Medical Subject Headings (MeSH)
Myobloc (rimabotulinumtoxinB) Prescribing Information
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Membrane protein: vesicular transport proteins (TC 1F)
Synaptic vesicle
SNARE
Q-SNARE
SNAP25 SNAP29
Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19
Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE
Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3
Synaptotagmin
SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT8 SYT9 SYT10 SYT11 SYT12 SYT13 SYT14 SYT15 SYT16 SYT17
Other
Synaptophysin Synapsin
Small GTPase: RAB3A
COPI
Coatomer COPA COPB1 COPB2 COPD/Archain COPE COPG COPG2 COPZ1 COPZ2
Small GTPase: ARF
COPII
Coatomer SEC23A/SEC24A SEC13/SEC31
Small GTPase: SAR1A
RME/Clathrin
CLTA CLTB CLTC
Caveolae
Caveolin (CAV1 CAV2 CAV3)
Other/ungrouped
Vesicle formation
Adaptor protein complex 1:
AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:
AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:
AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:
AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:
DTNBP1 BLOC153
BLOC-2:
HPS3 HPS5 HPS6
BLOC-3:
HPS1 HPS4
Coats:
Retromer TIP47
Small GTPase
Dynamin DNM1 DNM2 DNM3
Other
EHD protein family: EHD1 EHD2 EHD3 EHD4
Sorting nexins
Vacuolar protein sorting: VPS13B VPS33B
SYNRG
See also vesicular transport protein disorders
Categories: Protein domainsProtein familiesSingle-pass transmembrane proteins
https://en.wikipedia.org/wiki/Synaptobrevin
Zero ionic layer is the main site of interaction in the core SNARE complex. Dipole-dipole interactions take place between 3 glutamine (Q) residues and 1 arginine (R) residue exposed in this layer. Despite that, the majority of the SNARE complex is hydrophobic because of the leucine zipper.[1] Extensively studied layers within the SNARE alpha-helical bundle are designated from "-7" to "+8". Zero ionic layer is at the center of the bundle, and thus designated as "0" layer.[2]
https://en.wikipedia.org/wiki/Zero_ionic_layer
https://en.wikipedia.org/w/index.php?title=Special:Search&limit=20&offset=20&profile=default&search=zero+dipole&ns0=1&searchToken=a0uxe9fl1p1mpqykx84iy22gq
Search: Zero Dipole (on Wikipedia)
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