JOURNAL OF GENERAL VIROLOGY Volume 102, Issue 3
Review Article Open Access
Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19 Open Access
Molly K. Roe1, Nathan A. Junod1ORCID icon, Audrey R. Young1, Dia C. Beachboard2ORCID icon, Christopher C. Stobart1ORCID icon
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First Published: 28 January 2021
The first ester-based compounds to be developed were benzotriazole ester-based and irreversibly acylated the C145 within the active site [93]. Next, chloropyridine-esters were tested and found to have potent inhibitory activity against nsp5. CE-5 is one of the chloropeptidyl esters that has been extensively studied and shown to have broad activity across several CoVs.
https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001558
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