Post-transplant lymphoproliferative disorder (PTLD) is the name given to a B-cell proliferation due to therapeutic immunosuppression after organ transplantation. These patients may develop infectious mononucleosis-like lesions or polyclonal polymorphic B-cell hyperplasia. Some of these B-cells may undergo mutations which will render them malignant, giving rise to a lymphoma.[citation needed]
In some patients, the malignant cell clone can become the dominant proliferating cell type, leading to frank lymphoma, a group of B cell lymphomas occurring in immunosuppressed patients following organ transplant.
| Post-transplant lymphoproliferative disorder | |
|---|---|
| Other names | PTLD |
| Specialty | Immunology |
https://en.wikipedia.org/wiki/Post-transplant_lymphoproliferative_disorder
No comments:
Post a Comment