Atmospheric pressure chemical ionization (APCI) is an ionization method used in mass spectrometry which utilizes gas-phase ion-molecule reactions at atmospheric pressure (105 Pa),[1][2] commonly coupled with high-performance liquid chromatography (HPLC).[3] APCI is a soft ionization method similar to chemical ionizationwhere primary ions are produced on a solvent spray.[4] The main usage of APCI is for polar and relatively less polar thermally stable compounds with molecular weight less than 1500 Da.[5] The application of APCI with HPLC has gained a large popularity in trace analysis detection such as steroids, pesticides and also in pharmacology for drug metabolites.[6]
https://en.wikipedia.org/wiki/Atmospheric-pressure_chemical_ionization
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