Leishmania tropica is a species of flagellate parasites that infects humans and hyraxes, and the cause of the disease Leishmaniasis RecidivansOr bugdadsore, a form of cutaneous leishmaniasis. L. tropica infection results in non-ulcerating disease. Cause Oriental sores<Korean J. Parasitol. 2007 Jun;45(2):103-9.> <Mahmoudzadeh-Niknam H1, Kiaei SS, Iravani D.>
https://en.wikipedia.org/wiki/Leishmania_tropica
Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis.[1] The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis.[2] For certain infections it is given with flucytosine.[3] It is typically given by injection into a vein.[2]
Common side effects include a reaction with fever, chills, and headaches soon after the medication is given, as well as kidney problems.[2] Allergic symptoms including anaphylaxis may occur.[2] Other serious side effects include low blood potassium and inflammation of the heart.[1] It appears to be relatively safe in pregnancy.[2] There is a lipid formulation that has a lower risk of side effects.[2] It is in the polyene class of medications and works in part by interfering with the cell membrane of the fungus.[1][2]
Amphotericin B was isolated from Streptomyces nodosus in 1955 at the Squibb For Medical Research Institute from cultures isolated from the streptomycete obtained from the river bed of Orinoco in that region of Venezuela[4] and came into medical use in 1958.[5][6] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[7] It is available as a generic medication.[2] The cost in the developing world of a course of treatment as of 2010 is between US$162 and 229.[1]
https://en.wikipedia.org/wiki/Amphotericin_B
Leishmaniasis is a wide array of clinical manifestations caused by parasites of the trypanosomegenus Leishmania.[7] It is generally spread through the bite of phlebotomine sandflies, Phlebotomusand Lutzomyia, and occurs most frequently in the tropics and sub-tropics of Africa, Asia, the Americas, and southern Europe.[2][7] The disease can present in three main ways: cutaneous, mucocutaneous, or visceral.[2] The cutaneous form presents with skin ulcers, while the mucocutaneous form presents with ulcers of the skin, mouth, and nose. The visceral form starts with skin ulcers and later presents with fever, low count of red blood cells, and enlarged spleen and liver.[2][3]
https://en.wikipedia.org/wiki/Leishmaniasis
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