09-02-2021-1039 - Protein misfolding cyclic amplification (PMCA)

Protein misfolding cyclic amplification (PMCA) is an amplification technique (conceptually like PCR but not involving nucleotides) to multiply misfolded prions originally developed by Soto and colleagues.[1] It is a test for spongiform encephalopathies like CWD[2] or BSE.

https://en.wikipedia.org/wiki/Protein_misfolding_cyclic_amplification