08-25-2021-1113 - Acanthoma cyanide triple bond neoplastic pathology carcinoma protein lesion dysplasia LCA shows an intraepidermal proliferation of enlarged, atypical-appearing keratinocytes with a disorganized pattern. natis going back to germany for her cyanide science

Acanthoma

LCA shows an intraepidermal proliferation of enlarged, atypical-appearing keratinocytes with a disorganized pattern.

From: Diagnostic Pathology: Neoplastic Dermatopathology (Second Edition), 2017 

• Basal-Cell Carcinoma  
• Seborrheic Keratosis  
• Neoplasm 
• Papule 
• Hyperkeratosis 
• Lesion 
• Protein 
• Epidermis

• Acantholytic and Acantholytic Dyskeratotic Acanthoma

  In Diagnostic Pathology: Neoplastic Dermatopathology (Second Edition), 2017

  Acantholytic Acanthoma

  An acantholytic acanthoma is a solitary keratosis characterized by acantholysis (dyscohesion of keratinocytes) 

  , which is full thickness in this example. There is a lack of dyskeratosis (corp ronds and grains).

  Acantholytic Dyskeratotic Acanthoma

  An acantholytic dyskeratotic acanthoma is a solitary keratosis with acantholysis 

  and dyskeratosis (corp ronds 

  and grains 

  ). The overall architecture is flat and plaque-like.

  Acantholytic Acanthoma

  Intermediate-magnification view of an acantholytic acanthoma shows dyscohesion of keratinocytes (acantholysis) 

  . Dyskeratosis is not prominent.

  Acantholytic Acanthoma

  High-magnification view of an acantholytic acanthoma reveals acantholytic cells that lack cytologic atypia and have pink cytoplasm 

  due to clumped tonofilaments.

  Large Cell Acanthoma

  In Diagnostic Pathology: Neoplastic Dermatopathology (Second Edition), 2017

  Large Cell Acanthoma

  LCA shows an intraepidermal proliferation of enlarged keratinocytes 

  in a disorganized pattern. There is no basilar budding or overlying parakeratosis typical of an actinic keratosis. Note the prominent solar elastosis 

  in dermis.

  Large Cell Acanthoma at High Magnification

  Higher power of LCA shows enlarged keratinocytes 

  involving the mid to upper layers of epidermis with overlying basket-weave orthokeratosis. The dermis shows solar elastosis and mild chronic inflammatory infiltrate 

  .

  Large Cell Acanthoma at Low Magnification

  Another example of LCA shows an intraepidermal proliferation of enlarged squamous cells 

  . There is a lack of basilar budding or overlying parakeratosis typical of actinic keratosis.

  Large Cell Acanthoma at High Magnification

  The cells show nuclear enlargement, hyperchromasia, and focally prominent nucleoli 

  , but no mitotic figures are identified.

  https://www.sciencedirect.com/topics/medicine-and-dentistry/acanthoma

  
  

  
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  Synonyms:

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  Diphenidine is a homeomorph of the NMDA receptor channel blocker, MK 801, that has been identified as a designer drug.{26258} The (S)- and (R)- enantiomers of diphenidine have been reported to inhibit MK 801 binding to NMDA receptors in rat brain membranes with Ki values of 0.13 and 5.25 µM, respectively.{26258} It has been studied as a neuroprotective agent for the treatment of brain injury following hypoxia.{26257} This product is intended for forensic and research applications.

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