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Sunday, September 12, 2021

09-11-2021-2236 - Sulfabenzamide Tecovirimat orthopoxviruses

 Sulfabenzamide is an antibacterial/antimicrobial. Often used in conjunction with sulfathiazole and sulfacetamide (trade name – Sultrin) as a topical, intravaginal antibacterial preparation.[1]

Sulfabenzamide.svg

https://en.wikipedia.org/wiki/Sulfabenzamide


Tecovirimat, sold under the brand name Tpoxx,[2] is an antiviral with activity against orthopoxviruses such as smallpox and monkeypox. It was the first antipoxviral drug approved in the United States.[3]

The drug works by blocking cellular transmission of the virus, thus preventing the disease.[4] Tecovirimat has been effective in laboratory testing; it has been shown to protect animals from monkeypox and rabbitpox and causes no serious side effects in humans.[2] However, tecovirimat has never been used to treat a human with smallpox due to the disease's eradication.

Two million doses of tecovirimat are stockpiled in the US Strategic National Stockpileshould an orthopoxvirus-based bioterror attack occur.[5][6]

The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[7]

Tecovirimat.svg

https://en.wikipedia.org/wiki/Tecovirimat

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