09-12-2021-0125 - Tecovirimat Tpoxx orthopoxviruses smallpox not vaccinia or erythrematosis or overva sy or Eczema vaccinatum or Lupus erythematosus syst or Lyme or Autoimmune

 Tecovirimat, sold under the brand name Tpoxx,^[2] is an antiviral with activity against orthopoxviruses such as smallpox and monkeypox. It was the first antipoxviral drug approved in the United States.^[3]

The drug works by blocking cellular transmission of the virus, thus preventing the disease.^[4] Tecovirimat has been effective in laboratory testing; it has been shown to protect animals from monkeypox and rabbitpox and causes no serious side effects in humans.^[2] However, tecovirimat has never been used to treat a human with smallpox due to the disease's eradication.

Two million doses of tecovirimat are stockpiled in the US Strategic National Stockpileshould an orthopoxvirus-based bioterror attack occur.^[5][6]

The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.^[7]

https://en.wikipedia.org/wiki/Tecovirimat

Lupus erythematosus systemic Lyme Disease Autoimmune Disease

https://en.wikipedia.org/wiki/Thyroid_disease

From 1958 to 1977, the World Health Organizationconducted a global vaccination campaign that eradicated smallpox, making it the only human disease to be eradicated. Although routine smallpox vaccination is no longer performed on the general public, the vaccine is still being produced to guard against bioterrorism, biological warfare, and for monkeypox.[2][3]

ACAM2000 is a smallpox vaccine developed by Acambis. It was approved for use in the United States by the Food and Drug Administration (FDA) on 31 August 2007.^[9] It contains live vaccinia virus, cloned from the same strain used in an earlier vaccine, Dryvax. While the Dryvax virus was cultured in the skin of calves and freeze-dried, ACAM2000s virus is cultured in kidney epithelial cells (Vero cells) from an African green monkey. Efficacy and adverse reaction incidence are similar to Dryvax.^[13] The vaccine is not routinely available to the U.S. public; it is, however, used in the military and maintained in the Strategic National Stockpile.^[11][24]

A droplet of ACAM2000 is administered by the percutaneous route (scarification) using 15 jabs of a bifurcated needle. ACAM2000 should not be injected by the intradermal, subcutaneous, intramuscular, or intravenous route.^[25]

https://en.wikipedia.org/wiki/Smallpox_vaccine