Equine exertional rhabdomyolysis (ER, also known as tying up, azoturia, or Monday-morning disease) is a syndrome that damages the muscle tissue in horses. It is usually due to overfeeding carbohydrates and appears to have a genetic link.
Equine[edit]
In equine surgery, premedication with acepromazine has been shown to reduce the perianaesthetic mortality rate, possibly due to its actions as a sedative and anxiolytic.[4] It is less effective as a sedative if the horse is already excited.[23]
Additionally, acepromazine is used as a vasodilator in the treatment of laminitis, where an oral dose equivalent to "mild sedation" is commonly used, although the dose used is highly dependent on the treating veterinarian. While it is shown to elicit vasodilation in the distal limb, evidence showing its efficacy at increasing perfusion in the laminae is lacking. It is also sometimes used to treat a horse experiencing equine exertional rhabdomyolysis.[6]
Adverse effects[edit]
Side effects are not common, but the use of acepromazine in stallions should be used with caution (but is not absolutely contraindicated) due to the risk of paraphimosis and priapism.[5]
Acepromazine also lowers blood pressure, and should therefore be used with caution in horses that are experiencing anemia, dehydration, shock, or colic. It should not be used in horses dewormed with piperazine.[23]
https://en.wikipedia.org/wiki/Acepromazine#cite_note-3
https://en.wikipedia.org/wiki/Priapism
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