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Monday, September 13, 2021

09-13-2021-0230 - Schistosoma mansoni egg antigens directly stimulate the expression of the profibrogenic molecule osteopontin (OPN), ...liver collagen deposition in chronic murine schistosomiasis ...reliable tool for monitoring PZQ efficacy and fibrosis regression

Osteopontin (OPN) expression is modulated by Schistosoma mansoni egg antigen. [34]

Schistosoma mansoni egg antigens directly stimulate the expression of the profibrogenic molecule osteopontin (OPN), and systemic OPN levels strongly correlate with disease severity, suggesting its use as a potential morbidity biomarker. Investigation into the impact of Praziquantel use on systemic OPN levels and on liver collagen deposition in chronic murine schistosomiasis revealed that Praziquantel treatment significantly reduced systemic OPN levels and liver collagen deposition, indicating that OPN could be a reliable tool for monitoring PZQ efficacy and fibrosis regression. [35][36]


https://en.wikipedia.org/wiki/Osteopontin

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